肝硬化病人血清胱抑素C检测的临床意义  

Clinical significance of serum cystatin C in patients with cirrhosis

作　　者：胡超[1] 沈世强[1] 陈祖兵[1] 任波[1] 马中林[1] 

机构地区：[1]武汉大学人民医院普外科,430060

出　　处：《腹部外科》2012年第3期177-178,共2页Journal of Abdominal Surgery

摘　　要：目的探讨肝硬化病人血清胱抑素C（Cys C）水平检测的临床意义。方法选择184例肝硬化病人，其中血肌酐（SCr）、尿素氮（BUN）均无升高组150例，SCr、BUN轻中度升高组34例，另取体检健康者50．名作对照组，检测其血清CysC、SCr、BUN水平，SCr、BUN均无升高组肝硬化病人按Chil ＆ Pugh分级分为A、B、C三级。结果肝硬化病人血清CysC水平明显高于对照组（P〈0．01）。随着肝功能Chil ＆ Pugh分级升高，血清CysC水平升高程度逐级加重，SCr、BUN升高组CysC水平最高，各组之间差异有统计学意义（P〈0．05或P〈0．01）。结论血清CysC水平能更灵敏地反映肝硬化病人早期肾功能损害。Objective To study the clinical significance of serum cystatin C （Cys C） in patients with cirrhosis. Methods Serum Cys C was determined in 60 healthy subjects and 184 patients with cirrhosis who were divided into two groups according to the serum Cr （SCr） and BUN levels. There were 150 patients with cirrhosis whose SCr and BUN levels were normal, and 34 patients whose SCr and BUN levels were low-moderately increased. The patients with cirrhosis whose SCr and BUN levels were normal were divided into three groups according to Child-Puge standard： A, 13 and C. Results The level of serum Cys C was significantly higher in patients with cirrhosis than in healthy subjects （P 〈0. 01）, and elevated gradually with the elevation of Child-Pugh classification. The level of serum Cys C was the highest in the patients whose serum Cr and BUN levels were increased. There was also significant difference among groups （P〈0. 05 or P〈0. 01）. Conclusion Serum Cys C can be used as an effective marker to evaluate the early renal function in patients with cirrhosis.

关 键 词：肝硬化 肾病 早期诊断 胱抑素C 

分 类 号：R155.1[医药卫生—营养与食品卫生学]