大豆小分子肽增强小鼠免疫力的实验研究  

Experimental Study on the Immunity-enhancement Capability of Soybean Minor Peptides in Mice

作　　者：李硕[1] 陈宣钦[1] 李茂辉[2] 陈丽梅[1] 李昆志[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,云南昆明650500 [2]沈阳医学院预防医学系卫生检验中心,辽宁沈阳110034

出　　处：《大豆科学》2012年第3期466-469,473,共5页Soybean Science

基　　金：云南省中青年学术技术后备人才培养基金(2006PY01-10);云南省自然科学基金(KKSA201126058)

摘　　要：为通过动物实验检测大豆小分子肽(分子量300～700 Da)对免疫系统的影响及其增强免疫力的作用,分别给受试组小鼠经口灌胃低、中、高剂量(分别为3、6、9 g.kg-1.d-1)的大豆小分子肽溶液30 d后,进行各项免疫指标的检测。结果显示:大豆小分子肽能促进小鼠脾淋巴细胞的转化和迟发型变态反应,提高抗体生成细胞数和血清溶血素水平,增强腹腔巨噬细胞的吞噬能力;但对小鼠的NK细胞活性,单核—巨噬细胞的碳廓清能力,体重及免疫器官重量均无显著影响。这表明,大豆小分子肽具有增强机体免疫力的作用。To study and investigate the immunity-enhancement capability of soybean minor peptides（Molecular weight 300-700 Da）in mice.The immune indexes were determined after Kunming mice were orally fed soybean minor peptides at 3,6,9（g·kg-1·d-1）doses for consecutive 30 days.The results showed the ability of spleen-lymphocytes transformation and the number of phagocytizing chicken red blood cells in high-dose test groups was significant（P0.05）higher than the control group.Compared with the control group,there were significant differences of the left and right ear weight and the number of the antibody-producing cells,as well as the antibody numbers in the high and medium dose group（P0.05）.These results demonstrated the soybean minor peptides could significantly stimulate proliferation and transformation of the spleen-lymphocytes;promote delayed type hypersensitivity;raise the quantity of antibody-producing cells and increase the level of blood-serum erythrocytolysin and the phagotrophic function of peritoneal macrophages.However,no significant immunoragulatory effect was found in the activity of NK cells,expurgation effect by mononuclear phagocytes,weight of the mice and their immune organs.In conclusion,the soybean minor peptides had the capability of enhancing immunity.

关 键 词：大豆小分子肽 增强免疫力 小鼠 

分 类 号：S565.1[农业科学—作物学]