肺癌、宫颈癌细胞凋亡前后微量元素的变化  

Changes of Trace Elements in Cells of Lung Cancer and Cervix Cancer before Apoptosis and after Apoptosis

作　　者：李光城[1] 吴应荣[1] 黄宇营[1] 赵立敏 李景福[2] 张同存[2] 曹恩华[2] 

机构地区：[1]中国科学院高能物理研究所,北京100039 [2]中国科学院生物物理研究所,北京100101

出　　处：《光谱学与光谱分析》2000年第2期240-242,共3页Spectroscopy and Spectral Analysis

摘　　要：全反射荧光分析 (TXRF)比常规荧光分析 (XRF)具有更高的灵敏度。我们在北京正负电子对撞机同步辐射 3W 1A新光束线改建的同步辐射荧光站上 (更换了新探测器及相应谱仪系统 ) ,用TXRF对肺癌细胞和宫颈癌细胞进行了凋亡前后的研究 ,得到了这些细胞凋亡前后的荧光谱。从分析这些谱的结果我们可以看到 ,凋亡前后这些癌细胞中某些微量元素的含量有了变化 ,甚至是明显变化。从这些变化中我们可得到一些启发 ,如果能找到它们的变化规律是否可为治疗癌症做出一点贡献呢 ?The sensitivity of total reflection X ray fluorescence analysis (TXRF) is higher than normal X ray fluorescence analysis (XRF).The cells of lung cancer and cervix cancer were researched before apoptosis and after apoptosis employed the method of TXRF on new transformed synchrotron radiation XRF experimental station of new 3W1A beam line which built on Beijing Synchrotron Radiation Facility (BSRF) of BEPC (new detector and spectrometer systems).We acquired their fluorescence spectrum of various elements before apoptosis and after apoptosis.We discovered there were interesting results that changes even remarkable changes of some elemental contents had occurred in these cells before apoptosis and after apoptosis.These alterations of elemental contents have served an inspiration for us:if their regularities of change are found,we will hope that some contributions would be done at the treatments of cancer.

关 键 词：肺癌 宫颈癌 TXRF 癌细胞 凋亡 微量元素 

分 类 号：R734.202[医药卫生—肿瘤] R737.330.2[医药卫生—临床医学]