COX-2启动子区遗传变异与胃癌发病风险的关系  

Genetic polymorphisms in the promoter of Cyclooxygenase-2 and their association with the risk of gastric cancer

作　　者：景永茂 刘静[2] 李曙晶[3] 史卫俊[4] 成晓龙[4] 

机构地区：[1]灵石县人民医院普外科 [2]山西医科大学第一医院普外科 [3]山西医科大学儿科医学系 [4]山西医科大学解剖学教研室

出　　处：《中国优生与遗传杂志》2012年第5期24-25,30,共3页Chinese Journal of Birth Health & Heredity

基　　金：山西省高等学校优秀青年学术带头人基金项目(晋教科[2008]3号);国家自然科学基金项目81071625

摘　　要：目的 COX-2的过度表达在肿瘤的发生发展中起重要作用,本文探讨COX-2启动子区单核苷酸多态与胃癌易感性的关系。方法以聚合酶链反应-限制性片段长度多态性对155例胃癌患者和237例正常对照进行基因分型,以logistic回归的比值比(OR)及其置信区间(CI)来评估风险度。结果 COX-2-1290AG及GG基因型与胃癌的发病风险无关,OR为1.24(95%CI=0.66-2.35)。而携带COX-2-1195GA或-1195AA基因型的个体胃癌发病风险显著增加,OR分别为1.91(95%CI=1.05-3.47),2.71(95%CI=1.40-5.27)。单体型分析发现A_1290-A_1195单体型显著增加了胃癌的发病风险(OR=1.49,95%CI=1.10-2.01)。结论 COX-2启动子区-1195G→A遗传变异与胃癌发病风险相关。Objective ： Overexpression of cyclooxygenase （COX） - 2 has been implicated in the development ot cancer. This study aimed to evaluate the relationship between genetic variants in COX- 2 promoter and the susceptibility to gastric cancer （GC）. Methods ： Two COX - 2 polymorphisms （ - 1290A 〉 G and - 1195G 〉 A） were genotyped in 155 GC patients and 237 controls. Odds ratios （ORs） and 95% confidence intervals （CIs） were calculated by logistic regression model. Results： The genotype - 1290AG or GG did not show significant association with gastric cancer risk, and the OR was equal to 1.24 （95% CI = 0.66 - 2. 35）. For - l195G→A polymorphism, the ORs were 1.91 （95% CI = 1.05 -3.47） and2.71 （95%CI = 1.40 -5.27） for- 1195GA or - 1195AA genotype carriers, respectively. Haplotype analysis showed that the A_ 1290 -A_ 1195 haplotype was associated with increased risk for gastric cancer, compared with the A_1290 - G_1195 haplotype （OR = 1.49, 95% CI = 1.10 -2. 01 ）. Conclusion： Our results sug- gested that the COX- 2 promoter -1195G→A polymorphisms were associated with increased risk of gastric cancer.

关 键 词：COX-2 启动子 基因多态 胃癌 发病风险 

分 类 号：R735.2[医药卫生—肿瘤]