急性脑梗死并发代谢综合征患者HMGB1水平与脑动脉狭窄的相关性研究  

The relationship between HMGB1 and cerebral artery atherosclerotic stenosis in patients with acute cerebral infarction complicated by metabolic syndrome

作　　者：徐海洲[1] 朱立勋[2] 何建[1] 

机构地区：[1]第二军医大学附属长海医院急诊科,上海200433 [2]第二军医大学附属长海医院神经内科

出　　处：《临床急诊杂志》2012年第3期160-163,共4页Journal of Clinical Emergency

基　　金：上海市公共卫生优秀学科带头人基金(No:08GWD25)

摘　　要：目的:探讨急性脑梗死并发代谢综合征患者血清高迁移率族蛋白B1(high mobility group box-1,HMGB1)水平与脑动脉狭窄的相关性。方法:将74例急性脑梗死患者分为代谢综合征组和非代谢综合征组,分别检测血清HMGB1、甘油三酯、总胆固醇、高密度脂蛋白及低密度脂蛋白,并通过核磁共振血管成像明确有无颅内外动脉粥样硬化狭窄,计算各组的发生率。结果:代谢综合征组血清HMGB1水平明显高于非代谢综合征组(P<0.05),代谢综合征组脑动脉狭窄发生率显著高于非代谢综合征组(P<0.05),但行单因素Logistic回归分析提示脑动脉狭窄与血清HMGB1水平无显著相关性(P>0.05),而与代谢综合征有关(P<0.05)。结论:代谢综合征可能与脑动脉的粥样硬化狭窄有关,HMGB1可能参与此病理过程中,但HMGB1与脑动脉狭窄无明显相关性。Objective：To investigate the relationship between serum HMGB1 and cerebral artery atherosclerotic stenosis in patients with acute cerebral infarction complicated by metabolic syndrome （MS）. Method：74 patients with acute cerebral infarction were divided into MS group and non-MS group according to the criteria of MS. The serum concentration of HMGB1, TC, TG, HDL-C and LDL-C were detected in each group, and all patients un- derwent magnetic resonance angiography （MRA） to reveal the cerebral artery atherosclerotic stenosis. Result：The serum concentration of HMGB1 was higher in MS group than in non-MS group, （P〈0. 05）. The incidence of cer- ebral artery atherosclerotic stenosis was higher in MS group than in non-MS group, （P〈0.05）. The result of Lo- gistic regression analysis demonstrated that there was no correlation between HMGB1 and cerebral artery stenosis （P〉0.05）, whereas MS was associated with cerebral artery stenosis. Conclusion： MS was relevant to cerebral ar tery stenosis. HMGB1 may play a role in the progress of cerebral artery atherosclerosis. However, HMGB1 was not significantly associated with cerebral artery stenosis.

关 键 词：急性脑梗死 高迁移率族蛋白类 代谢综合征 动脉粥样硬化 

分 类 号：R743.33[医药卫生—神经病学与精神病学]