Issues in Freeze Drying of Aqueous Solutions  

水溶液的冷冻干燥问题(英文)

作　　者：王维 陈墨 陈国华 

机构地区：[1]College of Life Science,Dalian Nationalities University [2]Department of Chemical and Biomolecular Engineering,the Hong Kong University of Science and Technology [3]Department of Chemical Engineering,Dalian University of Technology

出　　处：《Chinese Journal of Chemical Engineering》2012年第3期551-559,共9页中国化学工程学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(21076042);Research Grants Council of Hong Kong SAR (RGC 600704)

摘　　要：Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry. The in-creased importance Of the process is gaining a worldwide interest of research. A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error em-piricism. Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying, material science and mechanisms of heat and mass transfer. This paper presents an overview on freeze ding of aqueous solutions based on publications in the past few decades. The important issuesof the process are analyzed.Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry.The increased importance of the process is gaining a worldwide interest of research.A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error empiricism.Formulation and process development need a systematical understanding of the physical chemistry of freezing and freeze drying,material science and mechanisms of heat and mass transfer.This paper presents an overview on freeze drying of aqueous solutions based on publications in the past few decades.The important issues of the process are analyzed.

关 键 词：SUBLIMATION supercooling desorption eutectic formation EXCIPIENT glass transition 

分 类 号：TQ02[化学工程]