急性鼠脑缺血时选择性酶抑制剂的脑保护作用  

Investigation of neuroprotective effects of 7-nitroindazole administrated during the focal cerebral ischemia in rats

作　　者：余华峰[1] 刘艳[1] 刘玉军 宋晓红 徐庆忠 冯景阳 耿稚萍 郭淮莲 张勇[1] 卢志达 

机构地区：[1]首都医科大学附属同仁医院神经内科,北京100730 [2]首都医大神经科学研究所,北京100054 [3]宣武医院病理科,北京100053

出　　处：《中风与神经疾病杂志》2000年第2期69-71,共3页Journal of Apoplexy and Nervous Diseases

基　　金：首都医科大学基础临床合作基金!资助课题 ( No:983 7)

摘　　要：目的　研究 7-硝基吲唑 (7- NI)在大鼠脑缺血后的保护作用。方法　用线栓法建立大鼠大脑中动脉缺血模型。用 7- NI(选择性 n NOS抑制剂 )研究了鼠脑缺血过程中脑组织 NOS活性变化 ,脑梗死体积以及梗死外周区神经元变化。结果　 7- NI明显抑制了神经元型 NOS活性 ,减少了脑梗死体积并显著减轻了神经元缺血早期变性变化。结论　 7- NI对缺血急性期脑组织有明显保护作用。Objectives To study the protective role of 7 nitroindazole(7 NI)on the focal cerebral ischemia in rats. Methods The rat model of focal cerebral ischemia were established with middle cerebral artery occlusion by the suture method 7 NI. The selective inhibitor 7 NI of neuronal nitric oxide synthase were used for investigating effects of NOS change in the focal ischemic brain tissues and changes of the cerebral infarct volume and neurons on the peripheral regions of cerebral infarct. Results 7 NI could significantly inhibit the nNOS activity,decreased infarct volume and attenuated degenerative change of neurons in early ischemic stage. Conclusions The results implied that the 7 NI had definite protective effects on the brains in ischemic acute stage.

关 键 词：脑缺血 选择性酶抑制剂 鼠 脑保护作用 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学]