PRL-3在喉癌组织中的表达及与MVD的相关性  

The expression of phosphatase of regenerating liver-3 and its correlation with microvessel density in laryngeal carcinoma tissue

作　　者：陈承波[1] 

机构地区：[1]浙江省余姚市人民医院耳鼻咽喉科,浙江余姚315400

出　　处：《中国现代医生》2012年第17期37-38,42,共3页China Modern Doctor

摘　　要：目的探讨PRL-3在喉癌组织中的表达及与MVD的相关性。方法采用免疫组化法及高倍镜检测定65例喉鳞状细胞癌患者癌组织及癌旁组织PRL-3表达及MVD计数。结果喉癌组织和癌旁组织各65例,PRL-3阳性分别为44例和6例,阳性率分别为67.69%、9.23%,差异有高度统计学意义(P<0.001)。不同分化程度、TNM分期及有无淋巴结转移组PRL-3阳性率及MVD计数之间差异有统计学意义(P<0.05)。PRL-3阳性及MVD计数均与病理分化程度呈负相关(P<0.05)。PRL-3表达与MVD计数呈正相关(P<0.05)。结论 PRL-3在喉鳞状细胞癌组织高表达并与恶性肿瘤浸润和转移有关,可作为新的肿瘤标志物监控喉鳞状细胞癌进展。Objective To investigate expression and correlation of phosphatase of regenerating liver-3 （PRL-3） and MVD in laryngeal carcinoma. Methods Though Immunohistochemical staining and microscopic detecting the expression PRL-3 and MVD count of 65 cases in laryngeal squamous cell carcinoma cancer tissue. Results Laryngeal carcinoma and adjacent tissues each of 65 cases, PRL-3 were 44 positive eases and 6 cases, the positive rate each was 67.69%, 9.23%, the differ- ence was statistically significant （P 〈 0.001）. PRL-3 positive rate and MVD count among different degree of differentiation, TNM stage and lymph node metastasis rate were significantly （P 〈 0.05）. PRL-3 positive rate and MVD counts were nega tively correlated with pathological differentiation （P 〈 0.05）. PRL-3 expression and MVD count was positively correlated （P 〈 0.05）. Conclusion PRL-3 in laryngeal squamous cell carcinoma is high expression and related to invasion and metastasis of malignant tumors, could be used as a new tumor marker monitoring progress of laryngeal squamous cell carcinoma.

关 键 词：喉鳞状细胞癌 促肝细胞再生磷酸酶-3 微血管密度 

分 类 号：R739.65[医药卫生—肿瘤]