犬颈总动脉节段性阻断后内膜增生的研究  

Arterial intimal hyperplasia after segmental block of canine common carotid artery

作　　者：景在平[1] 曲乐丰[1] 曹贵松[1] 仲剑平[1] 

机构地区：[1]第二军医大学附属长海医院血管外科,上海200433

出　　处：《中华实验外科杂志》2000年第3期205-206,共2页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金资助项目! ( 3 9670 70 7)

摘　　要：目的　探讨节段性动脉阻断对阻断段动脉内膜增生的影响。方法　将 1 6条健康杂种犬随机分成 4组 ,解剖出右侧颈总动脉以微型动脉夹在距环状软骨各 2 .0cm的近、远端阻断颈总动脉 0、1 5、30和 60min ,术后 4周取标本进行切片观察及计算机图像分析。结果　阻断 1 5min组动脉内膜未见明显增生 ,阻断 30min和 60min组阻断段动脉见新生内膜形成 ,且后者内膜增生程度较前者严重 ,前者新生内膜中细胞成分多而后者以细胞间质为主。结论　术中节段性阻断动脉可致阻断段动脉内膜增生 ,阻断时间以 1 5min左右为宜 ,不宜超过Objective\ To study the influence of segmental artery block on its intimal hyperplasia. Methods\ Sixteen mongrel dogs were randomly divided into 4 groups: the right common carotid artery was mobilized and clamped 2.0 cm proximal and distal to the cricoid cartilage for 0, 15, 30 and 60 min respectively. Specimens were harvested 4 weeks later for microscopic examination and the pictures were analyzed by computer. Results\ Neointimal formation was absent in the group of blockage for 15 min, but present in groups of blockage for 30 and 60 min. The degree of intimal hyperplasia in 60 min group was more obvious than that of 30 min group. Cells made up the major component of neointima in 60 min group but extracellular matrix in 30 min group. Conclusion\ Segmental artery block during operation may result in intimal hyperplasia. The appropriate block duration was 15 min approximately, never beyond 30 min.\;

关 键 词：内膜增生 再灌注损伤 颈总动脉节段性阻断 犬 

分 类 号：R-332[医药卫生]