过氧亚硝酸盐在内皮细胞损伤中的作用  

Effects of peroxynitrite on the endothelial cells

作　　者：陈愉[1] 金惠铭[1] 

机构地区：[1]上海医科大学病理生理学教研室,上海200032

出　　处：《中国病理生理杂志》2000年第5期470-473,共4页Chinese Journal of Pathophysiology

摘　　要：A Review] Endothelial cells produce both superoxide and nitric oxide. Nitric oxide and superox- ide are known to react rapidly to form the stable peroxynitrite anion. Peroxynitrite mediates the oxidation of protein, lipid, deoxyribose and inhibits mitochondrial electron transport. Peroxynitrite may break DNA strands and activate poly(ADP - ribose) syntheatase. If the reaction is excessive, it results in a depletion of intracelular NAD+ and ATP. There is ultimately cell death.A Review] Endothelial cells produce both superoxide and nitric oxide. Nitric oxide and superox- ide are known to react rapidly to form the stable peroxynitrite anion. Peroxynitrite mediates the oxidation of protein, lipid, deoxyribose and inhibits mitochondrial electron transport. Peroxynitrite may break DNA strands and activate poly(ADP - ribose) syntheatase. If the reaction is excessive, it results in a depletion of intracelular NAD+ and ATP. There is ultimately cell death.

关 键 词：亚硝酸盐类 血管内皮细胞 一氧化氮 

分 类 号：R543.02[医药卫生—心血管疾病]