VEGFR-3、podoplanin和CD34标记阳性脉管在宫颈癌中的表达及意义  

Expressions and significances of VEGFR-3,podoplanin,and CD34 labeled positive vessels in cervical cancer

作　　者：王杜平[1] 张颖[1] 王庆一[1] 

机构地区：[1]广东省珠海市妇幼保健院,519000

出　　处：《中国妇幼保健》2012年第19期3007-3010,共4页Maternal and Child Health Care of China

基　　金：广东省珠海市科技局基金资助项目〔珠科2009-42〕

摘　　要：目的:研究VEGFR-3、podoplanin和CD34标记的阳性脉管在宫颈癌组织中表达的特点,分析其与肿瘤临床病理特点之间的关系。方法:采用双标及单标免疫组化方法检测58例宫颈鳞癌组织VEGFR-3、podoplanin和CD34标记阳性脉管的密度。结果:癌灶边缘组织VEGFR-3和podoplanin阳性脉管密度显著高于癌组织(P<0.05),也显著高于对照组宫颈组织(P<0.05);癌灶边缘组织和癌组织CD34阳性脉管密度差异无统计学意义(P>0.05),均高于对照组宫颈组织(P<0.05)。Ⅱa期组癌灶边缘组织VEGFR-3、podoplanin和CD34阳性脉管密度分别为17.46±2.65、14.36±1.21、17.98±4.13显著高于Ⅰb期组的13.52±1.23、10.58±3.25、13.75±3.38(P<0.05);淋巴结转移组癌灶边缘组织VEGFR-3和podoplanin阳性脉管密度18.68±0.89和14.67±3.72显著高于无淋巴结转移组11.45±3.56和10.77±2.65(P<0.05),CD34阳性脉管密度在两组中表达差异无统计学意义(P>0.05)。结论:宫颈癌VEGFR-3、podoplanin和CD34表达与肿瘤临床分期有关,癌灶边缘组织VEGFR-3和podoplanin高表达与淋巴结转移亦密切相关,podoplanin有望成为宫颈癌淋巴结转移预后的一种可靠标志物。Objective ： To research the Characteristics of expressions of endothelial growth factor receptor - 3 （ VEGFR - 3 ）, podoplanin, and CD34 labeled positive vessels in cervical cancer tissue, analyze the relationship between their expressions and clinieopathological characteristics of cervical cancer. Methods ： Double - labeling and single - labeling immunohistoehemistry were used to detect the densities of VEGFR - 3, podoplanin, and CD34 labeled positive vessels in 58 cases with cervical cancer. Results ： The densities of VEGFR - 3 and podoplanin labeled positive vessels in adjacent tissue of cervical cancer were significantly higher than those in cervical cancer tissue （ P 〈 0.05 ） and cervical tissue in control group （ P 〈 0. 05 ） ; there was no statistically significant difference in the density of CD34 labeled positive vessels between adjacent tissue of cervical cancer and cervical cancer tissue （ P 〉 0.05 ） ; the densities of CD34 labeled positive vessels in adjacent tissue of cervical cancer and cervical cancer tissue were significantly higher than that in cervical tissue in control group （ P 〈 0. 05 ） . The densities of VEGFR - 3, podoplanin, and CD34 labeled positive vessels in adjacent tissue of cervical cancer of stage Ⅱ a were （ 17. 46 ±2. 65）, （ 14. 36 ± 1.21 ）, and （ 17. 98 ±4. 13）, respectively, which were significantly higher than those in adjacent tissue of cervical cancer of stage I b [ （ 13.52 ± 1.23 ） , （ 10. 58 ± 3.25 ） , and （ 13.75 ± 3.38 ） , respectively ] （ P 〈 0. 05 ） . The densities of VEGFR - 3 and podoplanin in adjacent tissue of cervical cancer in lymph node metastasis group were （ 18. 68 ± O. 89 ） and （ 14. 67 ± 3. 72 ）, respectively, which were significantly higher than those in adjacent tissue of cervical cancer in non -lymph node metastasis group [ （11.45 ± 3.56） and （ 10. 77 ±2. 65） , respectively] （P 〈0. 05） , there was no statistically significant difference in the density of CD34 la

关 键 词：宫颈癌 淋巴结转移 VEGFR-3 PODOPLANIN CD34 

分 类 号：R737.33[医药卫生—肿瘤]