脑梗死合并阻塞性睡眠呼吸暂停综合征患者血栓形成相关因素分析  

作　　者：陈德容[1] 

机构地区：[1]广东省东莞市长安医院,523843

出　　处：《当代医学》2012年第20期43-44,共2页Contemporary Medicine

摘　　要：目的观察分析脑梗死合并阻塞性睡眠呼吸暂停综合征患者血栓形成相关因素。方法选择自2009年1月～2009年12月收治的34例脑梗死合并阻塞性睡眠呼吸暂停综合征患者,作为观察组;同时选择收治的随机抽取的33例阻塞性睡眠呼吸暂停综合征排除脑梗死患者作为对照组1,另选择来检查的33例脑梗死排除阻塞性睡眠呼吸暂停症患者,作为对照组2;观察3组患者的体重指数、内皮素水平及PSG指标、血液流变学指标。结果 3组患者体重指数差异无统计学意义,但观察组内皮素水平(133.5±49.7)pg/ml,明显高于对照组1、2,差异有统计学意义(P<0.05);观察组患者PSG参数AH(I61.3±14.7)、LAT(88.1±23.3)、SaO2<0.9(476.8±45.2)、LSaO(254.6±1.3)与对照组1、2对比,差异有统计学意义(P<0.05);3组患者血液流变学指标对比,观察组全血黏度(2.3±0.4)、PAG(81.3±9.4)、Fi(b3.2±11.2)明显高于各对照组,PT(8.7±0.9)明显低于各对照组,差异有统计学意义(P<0.05)。结论睡眠呼吸暂停综合征使脑梗死患者的血栓形成的相关因素水平增加,促进血栓的形成,加速脑血管动脉硬化症状的发生,是较为危险的脑梗死症状。Objective To observe and analyze the related factors of cerebral infarction with obstructive sleep apnea syndrome in patients with thrombosis.Methods In our hospital from January 2009 to December 2009 a total of 34 cases of cerebral infarction complicated with obstructive sleep apnea syndrome were selected as the observation group;at the same time in our hospital 33 patients with obstructive sleep apnea syndrome excluding cerebral infarction patients were chosen as a control group 1,33 cases of cerebral infarction exclusion of obstructive sleep apnea were chosen as a control group 2;BMI,endothelin and PSG index,preparing rheological index in three groups were observed.Results In 3 groups of patients with body mass index had no significant difference,but the observation group endothelin levels（133.5±49.7） pg/ml was significantly higher than that of the control group,1,2,the difference was statistically significant（P〈0.05）;the patients in the observation group PSG parameter AHI（61.3±14.7） LAT,（88.1± 23.3）,（476.8 ±45.2）,SaO2〈0.9LSaO2（54.6 ±1.3） and1 in the control group2,contrast,the difference was statistically significant（P〈0.05）;3 groups of hemorheological indexes in patients with contrast,controls the whole blood viscosity（2.3±0.4） PAG,（81.3±9.4） Fib,（3.2±11.2） was significantly higher than that of the the control group,PT,（8.7±0.9） was significantly lower than that of the the control group,the difference was statistically significant（P〈0.05）.Conclusion Sleep apnea syndrome can increase levels of thrombosis factors in patients with cerebral infarction,can promote thrombosis,accelerate cerebral arteriosclerosis symptoms occur,is an dangerous symptoms of cerebral infarction.

关 键 词：脑梗死 阻塞性睡眠呼吸暂停综合征 血栓 血液流变学 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R766[医药卫生—临床医学]