新城疫病毒联合化疗对晚期非小细胞肺癌的疗效和安全性评价  

Effect and Safety of the Newcastle Disease Virus Combined with Chemotherapy for Patients with Advanced Non-small Cell Lung Cancer

作　　者：华影[1] 陶秀娟[2] 郭翔宇[3] 王洪敏[4] 梁伟[5] 

机构地区：[1]山东省肿瘤医院肿瘤内科,济南市255017 [2]辽宁省肿瘤医院内六科 [3]辽宁省肿瘤医院内一科 [4]沈阳医学院附属奉天医院 [5]辽宁省肿瘤医院生物研究所

出　　处：《中国肿瘤临床》2012年第13期919-922,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨新城疫病毒在ⅢB、Ⅳ期非小细胞肺癌(NSCLC)化疗中的作用。方法:2005年7月～2008年5月,在辽宁省肿瘤医院收治的146例非小细胞肺癌患者,随机分为实验组与对照组。实验组73例,采用新城疫病毒联合长春瑞滨+卡铂方案化疗;对照组73例,单纯采用长春瑞滨+卡铂方案化疗。每28天为1个周期,化疗4个周期。每2个周期评价疗效,并监测治疗前后患者白细胞、血小板、T细胞亚群CD4/CD8变化。结果:实验组和对照组的有效率分别为50.68%和41.10%(P<0.05)。实验组不良反应较对照组轻,差异有统计学意义(P<0.05)。实验组治疗前后CD4/CD8分别为1.22+0.94和1.59±1.17,差异有统计学意义(P<0.05)。结论:新城疫病毒联合长春瑞滨+卡铂方案治疗ⅢB、Ⅳ期非小细胞肺癌(NSCLC)疗效好,不良反应轻,具有提高机体的免疫功能和改善患者生活质量的作用。To assess the effect and safety of the Newcastle disease virus in chemotherapy for patients with stages IIIB and IV non-small cell lung cancer （ NSCLC ）. Methods： A total of 146 patients with advanced NSCLC were enrolled in this study. The patients were evenly randomized to experimental and control groups. Newcastle disease virus combined with the NP regimen （ vinorelbine and carboplatin, n=73 ） was given to the experimental group, and NP regimen only （ n=73 ） was given to the control group. The chemotherapy was performed for four cycles every 28 days, and the therapeutic efficacy was evaluated every 2 weeks. The following indicators were observed： levels of hemoglobin, white blood cell, platelet, and T cell subpopulation in the blood, as well as short-term efficacy, adverse effects, and quality of life. Results： The response rate in the experimental and control groups were 50.68% and 41.10%, respectively （ P 〈 0.05 ）. The Karnofsky performance score were higher in the experimental group than in the control group （ P 〈 0.01）. Gastrointestinal reactions, impairment of renal functions, nausea, and vomiting, diarrhea, and myelosuppression were alleviated in the experimental group compared with the control group; the difference was significant （ P 〈 0.05 ）. The CD4/CD8 ratio increased in the experimental group （ P 〈 0.05 ） but decreased in the control group （ P〉0.05）. Conclusion： The Newcastle disease virus combined with the NP regimen shows a better therapeutic effect, reduces the adverse effects of chemotherapy, and improves the quality of life of patients with stages III and IV NSCLC.

关 键 词：新城疫病毒 非小细胞肺癌 药物疗法 长春瑞滨 卡铂 

分 类 号：R734.2[医药卫生—肿瘤]