mTOR调节CD4＋T细胞亚群分化及功能的研究进展  

Research advances of mTOR regulation on the differentiation and function of CD4^+T cell subsets

作　　者：胡世莲[1] 张伯彬[1] 尹辉[2] 古宏标[1] 

机构地区：[1]广东药学院病理生理学教研室,广州510006 [2]微生物学与免疫学教研室

出　　处：《免疫学杂志》2012年第8期718-721,共4页Immunological Journal

基　　金：广东省医学科研基金(A2008314);广东药学院“中青年骨干教师培养基金”(广药[2008]98号)

摘　　要：哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)属于磷脂酰肌醇激酶相关激酶蛋白质家族成员,是一种非典型丝氨酸/苏氨酸激酶。mTOR可整合来自营养、能量、生长因子和环境压力对细胞的刺激信号,调节下游蛋白p70S6K和4E-BP1活性而影响细胞生长。CD4+T细胞是一群具有重要免疫调节功能的淋巴细胞,其中不同亚群在机体免疫应答中的作用存在明显差异。近来研究证实,mTOR信号在CD4+T细胞亚群分化发育及功能活性中发挥重要的调节作用。Mammalian target of rapamycin （mTOR）, an atypical serine/threonine kinase, belongs to phosphatidylinositol kinase-related protein kinase family, mTOR can integrate all of signals from the nutrition, energy, growth factors, and environmental stress to cells, subsequently regulates downstream proteins p70S6K and 4E-BP1 activitv and affects affects cell growth.CD4＋T cells consist of a group of lymphocytes with important immune regulaory function,and different subgroups of CD4＋T cells a distinctive effect in the immune response.Recent studies have confirmed that mTOR signaling plays a vital regulatory role in the differentiation and activity of CD4＋T cell subsets.

关 键 词：MTOR CD4+T细胞 TREG细胞 分化 功能 

分 类 号：R392.11[医药卫生—免疫学]