5-HT和DA浓度与强迫症发病年龄及5-HTT基因多态性的关联研究  

Associate study of platelet concentration of 5-HT,DA with 5-HTT gene polymorphism and age of onset in OCD

作　　者：刘胜皇[1] 张新风[1] 周云飞[2] 

机构地区：[1]湖北省荆州市精神卫生中心,434000 [2]广东省深圳市康宁医院

出　　处：《精神医学杂志》2012年第3期215-216,共2页Journal of Psychiatry

摘　　要：目的探讨早发性强迫症与晚发性强迫症的五羟色胺和多巴胺浓度的差异。方法用高效液相色谱法(HPLC)及电化学探测仪测定59例早发性强迫症和60例晚发性强迫症患者血小板5-HT和DA浓度。结果早发性强迫症患者血小板5-HT浓度均显著低于晚发性强迫症(t=3.662,P<0.05);早发性强迫症和晚发性强迫症患者血小板DA浓度无显著性差异(t=0.479,P>0.05);强迫症5-HTT中S/S、S/L和S/L+基因型强迫症组之间的5-HT浓度无显著性差异(P>0.05)。结论早发性强迫症患者血小板5-HT浓度明显较晚发性强迫症降低,DA浓度与强迫症的发病年龄无明显关联。强迫症的五羟色胺浓度与五羟色胺转运体启动子区多态性无关联。Objective To study the difference of platelet concentration of 5-HT and DA between early-onset and late-onset obsessive-compulsive disorder （OCD）. Methods High performance liquid chromatography with electrochemical detection （HPLC-ECD） was used to determine the platelet concentration of 5-HT and DA in 59 early- onset and 60 late-onset OCD patients. Results The platelet concentration of 5-HT of early-onset OCD patients were significantly lower than that of late-onset OCD patients （ t = 3. 662, P 〈 0.05 ）. No significant difference was found in platelet concentration of DA between early-onset and late-onset OCD patients （ t = 0. 479, P 〉 0.05 ）. There was no significant difference in platelet concentration of 5-HT among patients with S/S, S/L and L/L genotype in early-onset OCD group, nor in late-onset OCD group. Conclusion The platelet concentration of 5-HT of early-onset OCD is significantly lower than that of late-onset OCD. DA concentration is not related with the age of onset of OCD. The platelet concentration of 5-HT. in OCD is not associated with the polymorphism of 5-HTFLPR gene.

关 键 词：早发性强迫症 晚发性强迫症 多巴胺浓度 五羟色胺浓度 

分 类 号：R749.79[医药卫生—神经病学与精神病学]