CIK细胞与LAK细胞对H-22腹水瘤的抑瘤作用  

Anti-tumor activity of CIK cells and LAK cells on the mice bearing H-22 tumor in vivo

作　　者：任欢[1] 邢淑贤[1] 周贵生[1] 王立荣 田景先[1] 李殿俊[1] 

机构地区：[1]哈尔滨医科大学免疫学教研室,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2000年第2期85-87,共3页Journal of Harbin Medical University

基　　金：黑龙江省教委科研基金! ( 970 0 0 12 )

摘　　要：目的　观察CIK细胞及LAK细胞对H 2 2荷瘤鼠的抗肿瘤作用。方法　建立H - 2 2荷瘤鼠肿瘤动物模型 ,静脉输入CIK细胞 3周做抗肿瘤治疗 ,同时设LAK对照 ;用同位素法检测经治疗后荷瘤鼠T细胞增殖及NK细胞毒活性。结果　CIK细胞对H 2 2荷瘤鼠的抗肿瘤作用显著强于LAK细胞 (抑瘤率分别是 5 4%vs2 7% ) ;并且CIK疗法的抗肿瘤作用可能与荷瘤鼠T细胞增殖活性增高有关。结论　CIK细胞对H 2Objective To evaluate the anti tumor activity of CIK (cytokine induced killer) cells on Kunming mice bearing H 22 tumor in vivo .Methods CIK cells were injected intravenously into the mice bearing H 22 tumor for 3 weeks and compared with LAK controls in the same time. Results CIK cells had significantly anti tumor effect (the median inhibitory rate was 54%) which was much higher than that of LAK cells(the median inhibitory rate was 27.1%); and the later experiment suggested that CIK therapy was correlated with inducing the proliferation of the mice spleen T cells other than the NK cytolytic activity. Conclusion CIK therapy was more effective on mice bearing H 22 tumor in vivo than that of LAK.

关 键 词：CIK细胞 LAK细胞 H-22腹水瘤 动物模型 

分 类 号：R73－36[医药卫生—肿瘤]