回药爱康方抗C57小鼠肺癌转移及影响bcl-2的表达  

Effects of Hui Medicine Aikangfang on Metastasis and bcl-2 Expression of Lung Cancer in C57 Mice

作　　者：马科[1] 马治国[2] 龙一梅[1] 周丽萍[3] 楚国庆[3] 边静[1] 周慧[1] 

机构地区：[1]宁夏医科大学中医学院内科教研室,银川750004 [2]宁夏医科大学附属中医医院内科 [3]宁夏医科大学附属总医院中医科

出　　处：《肿瘤防治研究》2012年第7期769-772,共4页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金资助项目(81160462);教育部春晖课题(Z2007-1-750004);宁夏回族自治区科技攻关课题[(2008)80]

摘　　要：目的观察回药爱康方对C57小鼠Lewis肺癌细胞转移的影响,并检测各组小鼠瘤组织bcl-2的表达。方法将55只C57荷瘤小鼠随机分为荷瘤模型组,环磷酰胺(CTX)组,回药爱康方低剂量组、回药爱康方低剂量加化疗组、回药爱康方高剂量加化疗组。治疗后,观察各组小鼠肺表面转移灶和bcl-2蛋白的表达情况。结果 (1)肺转移灶的变化:与荷瘤模型组比较,其余各组小鼠肺转移灶差异有统计学意义(P<0.05)。(2)bcl-2表达情况:与荷瘤模型组比较,其余各组bcl-2的表达差异有统计学意义(P<0.01)。结论回药爱康方有抗小鼠肺癌转移和降低bcl-2表达的作用。Objective To observe metastatic effect of Hui medicine Aikangfang in C57 mice Lewis lung cancer cells and test bcl-2 expression in each mice tumor tissue.Methods Fifty-five tumor-bearing mice were randomly divided into model group,chemotherapy（CTX） group,low-dose group,low-dose with chemotherapy group and high-dose with chemotherapy group.After treatment,observing the lung surfaces metastasis and bcl-2 protein expressions of each mouse.Results（1） Lung metastases changes：compared with tumor-bearing model,the more than mice lung metastases is statistically significant difference（P〈0.05）.（2） bcl-2 expression：compared with tumor-bearing model,the more than bcl-2 expression is statistically significant difference（P〈0.01）.Conclusion Hui medicine Aikangfang can resist lung cancer metastasis in mice and reduce bcl-2 expression.

关 键 词：回药爱康方 LEWIS肺癌 BCL-2蛋白 

分 类 号：R734.2[医药卫生—肿瘤]