急性白血病患者P-糖蛋白和CD34的表达及其临床意义  

Clinical significance of P glycoprotein and CD34 expression of acute leukemia

作　　者：林秀梅[1] 谢兆霞[1] 祝平安 

机构地区：[1]湖南医科大学附属湘雅医院血液科,长沙410008 [2]衡阳1415医院血液科,衡阳421002

出　　处：《湖南医科大学学报》2000年第2期171-172,共2页Bulletin of Hunan Medical University

摘　　要：用免疫细胞化学ABC法检测 30例急性白血病患者骨髓单个核细胞P 糖蛋白 (P 1 70 )和CD34的表达。结果示 :P 1 70或CD34表达在急性非淋巴细胞白血病组和急性淋巴细胞白血病组之间的差异不明显 ( P >0 .0 5) ;P 1 70或CD34阳性表达组临床疗效差 ,与阴性表达组相比差异明显 (P <0 .0 5)。提示 。The expression of P glycoprotein(P 170) and CD34 was detected in the bone marrow mononuclear cells of 30 patients with acute leukemia by immunocytochemical technique using JSB 1 and Tk 3 monoclonal antibody. The results were that expression of P 170 and CD34 had no signficant difference between acute nonlymphoblastic leukemia and acute lymphoblastic leukemia(P>0.05). The clinical therapeutic effect was poor in P 170 or CD34 positive patients and had significant difference compared with those negative patients(P<0.05). Judgments of therapeutic effect for acute leukemia can be improved by detecting the expression of P 170 and CD34 simultaneously. [

关 键 词：急性白血病 P-糖蛋白 CD34 基因表达 

分 类 号：R733.71[医药卫生—肿瘤]