补充叶黄素对早期老年性黄斑变性患者黄斑色素密度的影响  

Effects of lutein supplementation on macular pigment optic density in patients with early age-related macular degeneration

作　　者：童念庭[1] 张薇[1] 宫媛媛[1] 张珍珍[1] 吴星伟[1] 

机构地区：[1]上海交通大学附属上海市第一人民医院眼科上海市眼底病重点实验室

出　　处：《中华眼底病杂志》2012年第4期372-375,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：上海市眼底病重点实验室开放课题基金（07Z22911）

摘　　要：目的 观察早期老年性黄斑变性（AMD）患眼黄斑色素密度（MPOD）变化以及补充叶黄素对MPOD变化的影响。方法 通过矫正视力、眼底照相、间接检眼镜、光相干断层扫描检查确诊并排除其他眼病的42例早期AMD患者42只患眼和42只正常对侧眼纳入研究。所有患者予以每日口服叶黄素15.1 mg，持续1个月。干预前后采用异色闪烁光度测量法检测其双眼的MPOD值，对比分析补充叶黄素前后MPOD变化值与补充叶黄素前MPOD值的关系。结果 补充叶黄素前AMD眼和正常对侧眼的MPOD平均值分别为0.347±0.182和0.426±0.173，二者比较，差异有统计学意义（t=-2.042，P=0.044）。补充叶黄素后AMD眼和正常对侧眼的MPOD平均值分别为0.406±0.155、0.446±0.128，二者比较，差异无统计学意义（t=-1.283，P=0.203）。与补充叶黄素前比较，补充叶黄素后AMD眼的MPOD有增高趋势，但其差异无统计学意义（t=-1.594，P=0.115）。AMD眼（r=-0.552，P=0.000）和正常对侧眼（r=-0.731，P=0.000）补充叶黄素前后MPOD变化值与补充叶黄素前MPOD值均有显著的负相关性。结论 早期AMD患眼MPOD较正常对侧眼降低；补充叶黄素对于提高早期AMD患眼MPOD有一定作用，其作用强度与治疗前MPOD值呈负相关。Objective To measure the macular pigment optical density （MPOD） and investigate the effects of lutein supplementation on MPOD in patients with early age-related macular degeneration （AMD）.Methods Forty-two early AMD eyes, which have been diagnosed by visual acuity, fundus photography and indirect ophthalmoscopy, and 42 fellow eyes were enrolled in this study. Lutein was administered in dose of 15.1 mg daily for one month. The MPOD value before and after lutein supplementation were measured by heterochromatic flicker photometry. The relationship between the MPOD value and lutein supplementation was analyzed.Results The MPOD value of AMD eyes and fellow eyes before lutein supplementation was 0.347±0.182 and 0.426±0.173 respectively, the difference was statistically significant （t=-2.042,P=0.044）. The MPOD value of AMD eyes and fellow eyes after lutein supplementation was 0.406±0.155 and 0.446±0.128 respectively, the difference was not statistically significant （t=-1.283,P=0.203）. For AMD eyes, there was an increasing trend of MPOD values after lutein supplementation, but no statistically significant differences （t=-1.594,P=0.115）. Furthermore, there was a negative correlation between the changes of MPOD and initial MPOD in both AMD eyes （r=-0.552,P=0.000） and the fellow eyes （r=-0.731,P=0.000）.Conclusions Early AMD eyes have less MPOD. Lutein supplementation may play a role in enhancing the MPOD in these eyes.

关 键 词：黄斑变性/预防和控制 叶黄素/治疗应用 黄斑/生理学 

分 类 号：R774.5[医药卫生—眼科]