原发性胆汁性肝硬化患者临床与病理学特点  

Clinical and pathology analysis of patients with primary biliary cirrhosis

作　　者：陶森[1] 胡莎莎[1] 邵凤珍[1] 

机构地区：[1]天津中医药大学第一附属医院肝胆科,天津300193

出　　处：《中西医结合肝病杂志》2012年第3期140-141,I0002,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:探讨不同程度的原发性胆汁性肝硬化(PBC)患者临床与病理特点。方法:根据PBC患者是否已进展至肝硬化将患者分为慢性胆管炎组(CC)和肝硬化组(LC),比较两组患者生化指标、肝脏组织学变化及临床并发症的差异,所有患者均给予熊去氧胆酸(UDCA)治疗,观察患者1年转归情况。结果:CC组患者病理损伤轻,对治疗敏感,LC组患者病理损伤重,治疗效果差,易出现进行性升高性黄疸、慢性肝功能衰竭。结论:PBC患者早期使用UDCA治疗有助于控制病情进展,当本病进展至肝硬化期则预后不良。Objective： To explore the clinical and pathological traits of primary biliary cirrhosis （PBC） in different stage. Meth- otis： Patients of PBC in the hospital were divided two groups by which were companied with chronic cholangtitis （CC） or not liver cir- rhosis （LC） . To compare with the biochemical and pathological index, complications in the different stage. After 1 year Ursodeoxy- cholic Acid （UDCA） was given, the prognosis of these patients were observed. Results： The pathological injury of CC group was less than the LC group, better to treatment. The mostly patients in LC group inclined to higher jaundice and chronic liver failure. Conclusion： Early treatment of UDCA is avail to ease the disease, but PBC with cirrhosis would be worse and have poor prog- nosis.

关 键 词：原发性胆汁性肝硬化 肝/病理学 熊去氧胆酸/治疗应用 

分 类 号：R575.2[医药卫生—消化系统]