交联透明质酸植入角膜超声生物显微镜观察  

Ultrasound biomicroscopy of cross-linked hyaluronic acid implanted in cornea

作　　者：郝念[1] 胡勇平[1] 张惠成[1] 董映[1] 刘小玲[2] 

机构地区：[1]杭州市第一人民医院眼科,杭州310006 [2]浙江省杭州师范大学

出　　处：《现代实用医学》2012年第6期614-616,共3页Modern Practical Medicine

基　　金：浙江省科技计划项目(2008c23058)

摘　　要：目的探讨交联透明质酸材料对兔角膜组织的生物学反应影响,评价其作为角膜组织工程支架材料的可行性。方法将交联透明质酸材料植入兔角膜基质层间内3个月,超声生物显微镜观察该材料在角膜内生物学反应。结果观察期内交联透明质酸材料与兔角膜基质愈合良好,超声生物显微镜检测到兔眼角膜中间有一高回声条带,随着观察时间延长,角膜中央高回声条带有减弱。结论交联透明质酸材料植入兔角膜后无排异等反应发生,材料逐渐降解吸收,其生物相容性良好,是一种理想的角膜组织工程支架材料。Objective To investigate the biological response of cross-linked hyaluronic acid as scaffold materials on rabbit＇s corneal, and evaluate the its feasibility for corneal tissue engineering. Methods Discs with 5.0 mm di- ameter of cross-linked hyaluronic acid were implanted into rabbits＇ interlamellar stromal pockets for a period of 3 months and the responses were observed by ultrasound biomicroscopy （UBM）. Results After 3 months, cross-lin- ked hyaluronic acid scaffold materials fused with rabbits＇ corneal stroma without rejected reaction. UBM showed there was a high echo stripe in the rabbits＇ corneal, and the echo stripe declined within observation period. Con- clusions Embedded cross-linked hyaluronic acid does not cause inflammatory reaction or rejected reaction, and the biocomoatibilitv of these materials is good.

关 键 词：透明质酸 超声生物显微镜 支架材料 生物相容性: 

分 类 号：R779.65[医药卫生—眼科]