慢性氟中毒对大鼠切牙釉质形态的影响  

Influences in enamel of rat incisor exposed to chronic fluorosis

作　　者：刘盘龙[1] 周红艳[1] 梅予锋[1] 

机构地区：[1]南京医科大学口腔医学研究所.附属口腔医院儿童口腔预防科,江苏南京210029

出　　处：《口腔生物医学》2012年第2期71-73,共3页Oral Biomedicine

基　　金：江苏高校优势学科建设工程资助项目;江苏省血地寄防应用性科研课题(X200916)

摘　　要：目的:观察慢性氟中毒下大鼠下颌切牙釉质形态改变,建立评价大鼠氟斑牙病变程度的方法。方法:将20只Wistar大鼠按性别随机分为4组,实验雌雄二组饮用浓度为100mg/L的氟化钠双蒸水,对照雌雄二组单纯饮用双蒸水,观察8周。在自然光下,观察记录大鼠下颌切牙釉质形态改变,使用改良氟斑牙指数评价氟斑牙进展程度。结果:相比对照组,饮氟组大鼠随着氟暴露时间的增加,下颌切牙釉质透明度、光泽度及其受累范围等发生不同程度的变化;相同条件下,不同性别大鼠间氟斑牙指数无显著差异(P>0.05)。结论:改良氟斑牙指数可以客观评价大鼠氟斑牙病变程度。Objective ： To observe the changes in enamel of rat incisor under chronic fluorine poisoning, and establish a new index for evaluation of dental fluorosis in rat. Methods ：20 Wistar rats were randomly divided into four groups by gender. Control groups were di- vided into male and female group ,fed with double-distilled water. Fluorosis groups were fed with double-distilled water containing 100 mg/L of F- for 8 weeks. Under natural light, the changes of the mandibular incisor enamel were recorded by digital camera. The pro- gress of dental fluorosis was evaluated by an improved dental fluorosis index. Results：Compared with control group, the enamel of dental fluorosis changed in different degrees, such as clarity, glossiness, surface defects. The progress of dental fluorosis had a significantly in- creased by drinking fluoride time. Under the same condition, dental fluorosis index of the different genders had no significant difference in sex （P 〉 0.05）. Conclusions： The improved dental fluorosis index can be used to evaluate the severity of dental fluorosis in rats objectively.

关 键 词：氟斑牙 氟斑牙指数 WISTAR大鼠 性别 

分 类 号：R781.2[医药卫生—口腔医学]