结直肠癌组织中趋化因子受体4、白介素-6的表达及其在血管生成中的作用  

Expression of chemokine receptor 4 and interleukin-6 in colorectal tumor and their significance in angiogenesis

作　　者：张丽娟[1] 王晨昱[1] 杨爱军[1] 刘伟[1] 李敏[1] 

机构地区：[1]兰州大学基础医学院,甘肃省新药临床前研究重点实验室,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2012年第2期15-18,共4页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的探讨结直肠癌组织中趋化因子受体4(CXCR4)、白介素-6(IL-6)的表达及其在血管生成中的作用。方法应用SP法对94例结直肠癌组织中CXCR4、IL-6、CD34的表达进行检测。结果结直肠癌组织中CXCR4蛋白阳性表达率为72.34%,IL-6蛋白阳性表达率为28.72%。CXCR4的表达与浸润深度和淋巴结转移有关(P<0.05);IL-6的表达与浸润深度、淋巴结转移无关。CXCR4的表达与IL-6的表达无相关性。CXCR4的表达与结直肠癌患者的浸润深度、淋巴结转移和微血管密度有相关性。IL-6的表达与结直肠癌患者各临床病理特征之间无关,而与微血管密度有相关性。结论 CXCR4和IL-6在结直肠癌组织中的表达明显升高,可能与结直肠癌血管生成有关,促进血管生成的作用在结直肠癌的发生发展中起关键作用。Objective To investigate the expression of chemokine receptor 4 （CXCR4） and interle- ukin-6 （IL-6） proteins in colorectal carcinoma and determine their clinical significance through finding their association with microvessel density （MVD） and their correlations with each other. Methods Immunohistochemistry staining was used to detect the expression of CXCR4, IL-6 pro- teins and CD34 in 94 cases of col0rectal cancer tissues. Results The respective expression levels of CXCR4 and IL-6 in colorectal cancer tissues were 72.34% and 28.72%. Expression of CXCR4 in colorectal carcinoma was correlated with invasive depth and lynph node metastasis （P 〈0.05）. Expression of IL-6 in colorectal carcinoma was not correlated to invasive depth, lynph node metas- tasis or tumor locus of the colorectal carcinoma. The expression of IL-6 in colorectal carcinoma was correlated with MVD. The expression of CXCR4 had no correlation with the expression of IL-6 in colorectal carcinoma. The expression of CXCR4 was positively correlated with tumorinvasive depth, lymph node metastasis and MVD in patients suffering from colorectM cancer. Conclusion The increase of the expression of CXCR4 and IL-6 in colorectM cancer tissue may relate with tumor angiogenesis and they may play a key role in colorectM cancer formation and metastasis.

关 键 词：结直肠癌组织 趋化因子受体4 白介素-6 血管生成 

分 类 号：R735.3[医药卫生—肿瘤]