孤独症危险因素探讨  

Analysis of Risk Factors in Patients with Autism

作　　者：张雅丽[1] 牛小媛[2] 

机构地区：[1]山西医科大学汾阳学院,032200 [2]山西医科大学第一医院

出　　处：《长治医学院学报》2012年第3期181-184,共4页Journal of Changzhi Medical College

摘　　要：目的:探讨孤独症的危险因素及其在孤独症发病中的作用。方法:选取孤独症儿童138名,与年龄、性别相匹配的138名身体健康、智力正常的儿童进行病例对照研究。统计方法采用t检验、χ2检验和非条件多因素Logistic回归分析,采用SPSS13.0统计软件进行数据处理。结果:χ2检验显示父母的文化程度、母亲先兆流产、孕早期感冒、是否正常孕周、缺氧窒息、高热惊厥、遗传史和母亲性格内向有统计学意义;非条件多因素回归分析结果显示,对孤独症发病的贡献值从大到小依次为遗传史、先兆流产、孕早期感冒、父亲的文化程度、产期异常、母亲的性格内向。结论:母亲孕产期并发症、患者长期重病、家庭情况、遗传史等均可能是孤独症的危险因素,尤其是遗传史及母亲的先兆流产与孤独症发病的关系最为密切。控制以上危险因素可能有助于预防和降低孤独症的发生率。Objective：To explore potential prenatal, perinatal, neonatal, developmental and family risk factors of autism trough case-control study. Methods ：138 children with autism （DSM-IV criteria） who come from a special autistic school and 138 normal children who come from the normal school matching by sex and age were investigated respectively. We analyze these data by t-test,：X^2 test and unconditional logistic regression. Results： There were significant association between autism and culture level of parents, threatened abortion, Influenza, pregnant week, neonate suffocates, convulsions, hereditary disease history, mother character. Conclusion： The unfavorable events in pregnant, delivery, the neonatal and developmental phase increase the risk of autism. We should take some effective to control these risk factors.

关 键 词：孤独症 危险因素 病例对照研究 

分 类 号：R749.8[医药卫生—神经病学与精神病学]