芒果脂油脂成分分析和体外促渗作用研究  

Analysis of Oil Components of Mango Seed Butter and Its Penetration Enhancing Effect in Vitro

作　　者：吴文澜[1] 梁菊[2] 董亚南[2] 陈姗[2] 

机构地区：[1]河南科技大学医学院,河南洛阳471003 [2]河南科技大学化工与制药学院,河南洛阳471003

出　　处：《河南科技大学学报（自然科学版）》2012年第4期96-99,10,共4页Journal of Henan University of Science And Technology:Natural Science

基　　金：河南省科技发展计划基金项目(092102210182);河南省教育厅自然科学研究计划基金项目(2011A350001)

摘　　要：利用气相色谱-质谱联用(GC-MS)分析了芒果脂所含的油脂成分。分析结果显示,芒果脂的6个主要成分及其质量分数分别是:棕榈酸为15.235%,油酸为78.041%,11-二十碳烯酸为0.425%,花生酸为4.681%,山俞酸为0.674%,木质素酸为0.549%。体外经皮渗透试验显示,芒果脂能够显著增加经皮给药制剂的皮肤透过率,氮酮组和芒果脂组对利多卡因的累积透皮量分别为794.840μg和1208.700μg,累积透皮率分别为7.95%和12.80%,芒果脂对模型药利多卡因的体外促渗作用一定程度上优于氮酮。In this paper,the oil components of mango seed butter were analyzed by GC-MS.The results show that the six main components of mango seed butter are hexadecanoic acid,oleic acid,11 -dodecenoicacid, arachidic acid,behenic acid,and tetracosanoic acid.The mass fraction of these components are 15.235%, 78.041%,0.425%,4.681%,0.674%,0.549%respectively.Skin penetration experiments in vitro show that the oil components of mango seed butter can significantly increase the transdermal penetrance of lidocaine.The accumulated permeation amounts of azone group and mango seed butter group are 794.84 jxg and 1208.7 g respectively,while the accumulated permeability are 7.95%and 12.8%.Penetration enhancing effect of mango seed butter in vitro for lidocaine is superior to azone in some degree.

关 键 词：芒果脂 气相色谱-质谱 油脂 透皮给药系统 促渗剂 

分 类 号：R944.9[医药卫生—药剂学]