盐酸纳美芬在颈髓损伤治疗中的疗效评价  

Evaluating the therapeutic effect of nalmefene hydrochloride in the treatment of cervical spinal cord injury

作　　者：李晨 宋斌 施永周 廖金平 谭俊铭 陈德纯 

机构地区：[1]解放军第九八医院急诊科,浙江省湖州市313000 [2]全军创伤修复重建中心,浙江省湖州市313000

出　　处：《中国医药》2012年第7期857-858,共2页China Medicine

基　　金：全军医学科研“十二五”课题（CWSllJ260）;南京军区医学科研课题（2007-14）

摘　　要：目的探讨盐酸纳美芬在治疗颈髓损伤中的疗效。方法将64例颈髓损伤患者完全随机平均分为治疗组与对照组，其中治疗组患者给予纳美芬0．3mg，静脉滴注，2次／d，连用14d；对照组给予盐酸纳洛酮2mg，静脉滴注，3次／d，连用14d。结果治疗组于治疗后3、6．9个月JOA评分增加值分别较对照组治疗后3、6．9个月后的JOA评分增加值高，2组比较差异有统计学意义[治疗后3个月：（6．1±0．5）分比（3．4±0．6）分；治疗后6个月：（7．3±0．8）分I；L（4．1±0．6）分；治疗后9个月：（9．0±0．6）分比（4．6±0．7）分；P〈0．05]。结论和纳洛酮相比，作为新一代阿片受体拮抗剂的纳美芬具有更强的阿片受体亲和性、更长的半衰期、更好的生物利用度和更高的安全性．可更好地用于治疗脊髓榻伤患者．Objective To evaluate the therapeutic effect of nalmefene hydrochloride in the treatment of spi- nal cord injury of cervical spine. Methods Sixty-four cases of spinal cord injury of cervical spine were investigated and these cases were divide equally into treatment group and control group randomly. The patients of treatment group （n = 32） were administrated 0.3 mg nalmefene hydroehloride （2 times per day） as intravenous drop infusion and lasted for 14 days, The patients of control group （n =32） were administrated 2 mg naloxone hydrochloride （3 times per day） as intravenous drop infusion and lasted for 14 days. Results The Japanese Orthopaedic Association （JOA） score of the treatment group was higher than that of the control group in 3,6 and 9 months with significant differences [（6.1±0.5） vs （3.4±0.6）;（7.3±0.8） vs （4.1±0.6）;（9.0±0.6） vs （4.6 ±0.7）;P〈0. 05 ]. Conclusion The clinical research reveals that nalmefene hydroehloride has stronger affinity of opioid recep- tors, longer half-life, better bioavailability, higher security features compared with naloxone hydrochloride in the treatment of spinal cord injury.

关 键 词：脊髓损伤 颈椎 纳美芬 功能恢复 

分 类 号：R744[医药卫生—神经病学与精神病学]