连接蛋白43和上皮细胞钙黏蛋白在乳腺浸润性导管癌组织中表达的意义  

Significance of expressions of connexin 43 and E-cadherin in invasive ductal carcinoma

作　　者：高一菁[1] 陈战[1] 李锐[1] 谢晓梅[1] 涂永久[1] 

机构地区：[1]解放军第174医院普通外科,福建省厦门市361003

出　　处：《中华乳腺病杂志（电子版）》2012年第3期26-29,共4页Chinese Journal of Breast Disease(Electronic Edition)

摘　　要：目的探讨间隙连接蛋白43(connexin43,Cx43)及上皮细胞钙黏蛋白(E-cadherin,E-cad)在乳腺浸润性导管癌组织中表达的作用。方法采用Elivision免疫组织化学法对17例正常乳腺组织、42例乳腺良性病变组织(18例乳腺纤维腺瘤、24例纤维腺病)及41例乳腺浸润性导管癌组织中的Cx43和E-cad表达进行检测。统计分析采用卡方检验、配对计数资料的McNemar检验及Kappa检验。结果 Cx43和E-cad在浸润性导管癌中表达明显降低,与TNM分期、病理组织学分级及淋巴结转移有关(P<0.050)。在浸润性导管癌中Cx43和E-cad蛋白表达一致性较好(Kappa值=0.466,P=0.003)。结论 Cx43和E-cad的表达下降可能在乳腺浸润性导管癌发生和发展过程中发挥一定的作用。联合检测Cx43和E-cad有利于判断肿瘤的分化程度及浸润转移情况。Objective To investigate the expressions of connexin 43 （ Cx43 ） and E-cadherin （E-cad） in invasive duetal carcinoma（IDC） and their clinical significance. Method The expressions of Cx43 and Ecad proteins were detected in 41 cases of breast invasive ductal carcinoma,42 cases of benign breast diseases and 17 cases of normal breast tissues by immunohistochemical Elivision method. Chi-square test, McNemar test and Kappa test were used for statistical analysis. Results The expressions of Cx43 and E-cad were remarkably decreased in IDC tissues. Both Cx43 and E-cad expressions were significantly related with TNM stage, histologie grading and lymphatic metastasis in breast IDC （P〈0. 050）. There was better agreement between Cx43 and E-cad expressions （ Kappa = 0. 466, P = 0. 003 ）. Conclusion The decreased expressions of Cx43 and Ecad in IDC might play a role in carcinogenesis and development of IDC. It is conducive to judge tumor differentiation and invasion status by detecting Cx43 and E-cad together.

关 键 词：乳腺肿瘤 连接蛋白43 上皮细胞钙黏蛋白 免疫组织化学法 

分 类 号：R737.9[医药卫生—肿瘤]