肝硬化患者血清C型利钠肽前体氨基末端肽水平的变化  

Changes of serum NT-proCNP in patients with liver cirrhosis

作　　者：梁彬[1] 郭政东[1] 解芳[1] 

机构地区：[1]中国医科大学高等职业技术学院检验教研室,辽宁沈阳110001

出　　处：《胃肠病学和肝病学杂志》2012年第7期611-612,共2页Chinese Journal of Gastroenterology and Hepatology

基　　金：辽宁省科技厅自然科学基金项目(201102279)资助

摘　　要：目的探讨肝硬化患者血清C型利钠肽前体氨基末端肽(amino-terminal pro-C-type natriuretic peptides,NT-proCNP)水平的变化及其与临床并发症的关系。方法选取65例肝硬化患者,56例肝纤维化患者和45例健康体检人群为研究对象。用ELISA方法测定血清中NT-proCNP的水平。结果肝硬化组血清NT-proCNP水平明显高于肝纤维化组和正常对照组,差异有统计学意义(P<0.01)。按肝硬化Child-Pugh’s分级,各级NT-proCNP水平无差异(P>0.05)。肝硬化患者血清NT-proCNP水平与肝腹水、静脉曲张出血和肝性脑病有关(P<0.05)。结论血清NT-proCNP水平与肝硬化的发生和发展有关,NT-proCNP水平升高可能是缓解肝硬化门脉高压的内源性代偿措施。Objective To observe the changes of serum amino-terminal pro-C-type natriuretie peptides （NT-proC- NP） in patients with liver cirrhosis, and to evaluate the relationship with clinical complication. Methods A total of 65 patients with liver cirrhosis, 56 patients with liver fibrosis and 45 healthy controls were recruited in this study. Serum level of NT-proCNP was measured by ELISA methods. Results Serum level of NT-proCNP in liver cirrhosis group was higher significantly than that in liver fibrosis group and healthy controls （P 〈0.01 ）. There was no difference according to Child-Pugh＇ s criteria of liver cirrhosis （P 〉 0.05）. Serum level of NT-proCNP was correlated to occurrence of asci- tes, varieeal bleeding and hepatic encephalopathy （P 〈 0.05）. Conclusion Serum NT-proCNP may be closely associ- ated with the progression of liver cirrhosis, and increase of NT-proCNP in patients with cirrhosis is an endogenous com- pensatory mechanism to reduce portal pressure.

关 键 词：肝硬化 C型利钠肽前体氨基末端肽 并发症 Child-Pugh’s分级 

分 类 号：R575[医药卫生—消化系统]