多药耐药基因MDR1 C3435T基因多态性对根除幽门螺杆菌疗效的影响  

Effect of MDR1 C3435T genetic polymorphism on the outcome of eradication of Helicobacter pylori infection

作　　者：陈东燕[1] 孙艳荪[1] 吴子刚[2] 乔珊[1] 林煜光[2] 

机构地区：[1]广东省深圳市北京大学深圳医院特诊病房,518036 [2]广东省深圳市北京大学深圳医院消化内科,518036

出　　处：《现代消化及介入诊疗》2012年第3期123-126,共4页Modern Interventional Diagnosis and Treatment in Gastroenterology

基　　金：深圳市科技计划项目(200602026)

摘　　要：目的研究多药耐药基因MDR1C3435T基因多态性对质子泵抑制剂联合阿莫西林与克拉霉素三联1周疗法根除幽门螺杆菌(Hp)治疗的影响。方法选取101例Hp阳性的慢性胃炎或消化性溃疡患者,分成2组,分别进入埃索美拉唑联合阿莫西林与克拉霉素方案(EAC)或奥美拉唑联合阿莫西林与克拉霉素方案(OAC)进行1周根除治疗。采用聚合酶链反应-限制性内切片段长度多态性(polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)的方法检测MDR1C3435T基因型,比较不同基因型患者之间Hp根除率的差异。结果 MDR1CC3435、C3435T和3435TT的Hp根除率分别为72.4%、88.2%和81.0%。MDR1C3435T各基因型组间Hp根除率比较均无显著性差异。结论 MDR1C3435T基因多态性与Hp根除疗效无显著相关性。Object To study the efficacy of one-week triple therapy with PPI plus amoxicillin and clar- ithromycin on eradication of Helicobacter pylori （H.pylori） infection in relation to P-glycoprotein（MDR1 C3435T） gene polymorphisms. Methods A total of 101 patients with H.pylori positive gastritis or peptic ulcer were assigned to receive 20 mg esomeprazole twice daily with 1 000 mg amoxiciUin twice daily and 500 mg clafithromycin twice daily （EAC group） or 20 mg omeprazole twice daily with 1 000 mg amoxicillin twice dai- ly and 500 mg clarithromycin twice daily （OAC group） for one-week. MDR1 C3435T alleles were determined by means of polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） assay. Results The eradication rates of H.pylori in CC34,35, C3435T and 3435TT were 72.4%, 88.2% and 81.0%, respective- ly. The patients withMDR1 C34,35T genetic polymorphism did not show any significant effect after treatment. Conclusion There was no significant relationship between the effect of H.pylori eradication and MDR1 C3435T genetic polymorphism.

关 键 词：MDR1 基因多态性 P-糖蛋白 埃索美拉唑 奥美拉唑 

分 类 号：R573.1[医药卫生—消化系统]