直肠癌经术中髂内动脉预置泵化疗109例报告  

Clinical study of chemotherapy via intraoperative preset pump in internal iliac artery on rectal cancer(report of 109 cases)

作　　者：陈焕新[1] 鲁瑞林[1] 郑乃国[2] 梅伟[1] 

机构地区：[1]四川省遂宁市第一人民医院外二科,四川遂宁629000 [2]第三军医大学西南医院普外科

出　　处：《西南国防医药》2012年第7期762-764,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨直肠癌化疗的有效途径。方法回顾性分析1993年3月～2008年11月收治的109例预置泵化疗的临床资料。Dukes B期33例,C期65例,D期5例和复发癌6例。首次给药在术后第7～14 d,30 d为一个治疗周期,共5～6个周期结束化学治疗。结果随访52～181个月,注药顺利完成全部疗程107例。36例有局部反应,为尿痛,会阴部胀痛下坠不适感,置管侧臀部皮肤"地图斑"样改变或伴轻度疼痛、瘙痒或水疱,多数短期恢复。全身反应:恶心腹泻等胃肠道反应107例,大多较轻,一般处理后缓解;WBC一般都有降低,但无低于2.0×109/L的严重者。结论和全身静脉化疗相比,本法有如下优点:(1)副作用低,如恶心、呕吐、白细胞降低等均较轻。(2)操作简便,安全,实用,可反复使用。(3)局部疗效较好。Objective To investigate the effective ways of chemotherapy on rectal cancer. Methods A retrospective analysis of clinical data was made among 109 cases receiving chemotherapy via preset pump in internal iliac artery（ILA） from March 1993 to November 2008. Among these eases ,63 ones were male, and 46 ones were female. Thirty three ones were in the Dukes Stage B ;65 ones in stage C;5 in stage D;6 ones had recurrent cancer. Administration for the first time was in d 7 - 14 after the operation,and 30 d was a treatment circle. The chemotherapy was completed after 5 or 6 circles. Results Follow up was made in 52 - 181 months. The whole course of treatment was successfully done in 107 cases. Local reaction occurred in 36 cases, which included odynuria, perineal distending pain and“map - like” piebald changes or mild pain ,pruritus, and blister on the gluteal skin near the part of pump insertion. Most symptoms were recovered in short tenn. The general reaction of gastrointestinal reactions such as nausea and diarrhia occurred in 106 cases, which mostly were mild and relieved after the conventional treatment. Their WBC generally decreased,but was not less than 2.0 x 10^9/L. Conclusion Compared with the systemic vein chemotherapy, this remedy has advantages as below： （ 1 ）lower side effect and comparatively milder symptoms such as nausea, vomiting, and decrease of WBC, etc ; （ 2 ） convenient, safe, and practical manipulation and repeatedly usable procedure;（3 ）good local therapeutic efficacy.

关 键 词：直肠癌 化疗 髂内动脉泵 

分 类 号：R735.37[医药卫生—肿瘤]