进展期胃癌术中植入中人氟安的临床观察  

Effect of Sustained Release 5-Fluorouracil on Advanced Gastric Cancer

作　　者：杜军[1] 张年庆[1] 李雷[1] 王雪[1] 

机构地区：[1]蚌埠医学院第一附属医院康复部外二科,安徽省蚌埠市233004

出　　处：《中华全科医学》2012年第8期1221-1222,共2页Chinese Journal of General Practice

摘　　要：目的评价进展期胃癌患者术中腹腔内植入缓释氟尿嘧啶植入剂进行腹腔化疗的安全性及疗效。方法对57例进展期胃癌患者进行回顾性研究:其中28例进行术中腹腔内植入缓释氟尿嘧啶植入剂进行腹腔化疗,术后1个月无化疗禁忌后行常规化疗。29例未行任何腹腔化疗,术后1个月化疗禁忌后行常规化疗。用药前:详询病史、全面体检;术前各项常规检查;同时观察恶心呕吐、发热、腹泻、腹痛等体征。术后观察切开愈合、肠梗阻等并发症;复查用药前各项检查指标。记录2年生存率。结果在化学性腹膜炎、切口感染和裂开、吻合口漏、腹腔感染以及粘连性肠梗阻这4个方面相比较两组均无明显差异。治疗组消化道反应的发生率高于对照组(P<0.05),但均为轻度反应,两组病例在骨髓抑制、肝功能异常和肾功能异常这3个方面相比较差异均无统计学意义(P>0.05)。两组病例1年生存率差异无统计学意义(P>0.05),治疗组相对于对照组的2年生存率差异有统计学意义(P<0.05)。结论进展期胃癌患者术中腹腔内植入缓释氟尿嘧啶植入剂是一种安全、有效的腹腔化疗方法。Objective To evaluate the effects and safety of sustained-release fluorouracil intraperitoneal implants on advanced gastric cancer.Methods All 57 cases with advanced gastric cancer were studied retrospectively： 28 cases received the sustained-release fluorouracil implants and 1 month later underwent the conventional chemotherapy.29 cases did not received intraperitoneal chemotherapy and 1 month later underwent the conventional chemotherapy.The information were collected before the chemotherapy,include the detail the history,complete physical examination,preoperative routine examination,simultaneous observation of nausea and vomiting,fever,diarrhea,abdominal pain and other symptoms.After the operation,the incision healing,intestinal obstruction and other complications were observed.The past examination index was rechecked,and 2 years survival rate was recorded.Results There was no statistically different in the chemical peritonitis,incision infection and dehiscence of abdominal abscess,anastomotic leakage,adhesion intestinal obstruction between the two groups.The gastrointestinal reaction rate is higher in the treatment group than that in the control group（P0.05） but the reaction were mild.There was no statistically different in the bone marrow inhibition,abnormal liver function and renal function abnormalities between the two group（P 0.05）.The difference in 2 years survival rate between the two groups was significant（P0.05）.Conclusion The sustained-release fluorouracil intraperitoneal implants are safe and effective for the advanced gastric cancer.

关 键 词：氟尿嘧啶植入剂 胃癌 腹腔化疗 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]