雷公藤多甙抑制化学烧伤性角膜新生血管的实验研究  

Tripterygium Polyglucoside inhibits corneal neovascularization in an chemical burn induced model

作　　者：黎燕英[1] 雷鹏[1] 陆守权[1] 杨春园[1] 王蕾[1] 

机构地区：[1]广东省第二人民医院眼科,中国广东省广州市510317

出　　处：《国际眼科杂志》2012年第8期1467-1469,共3页International Eye Science

摘　　要：目的:研究雷公藤多甙对角膜化学烧伤后新生血管形成的抑制作用。方法:取健康SD大鼠20只,采用750mL/L硝酸银溶液烧伤法制备大鼠角膜新生血管模型,随机分为对照组(化学烧伤后生理盐水点眼组)、雷公藤多甙组(烧伤后雷公藤多甙滴眼液点眼治疗),每组各10只。于化学烧伤后观察角膜新生血管的面积和角膜组织学形态改变。结果:化学烧伤后第14及28d,对照组角膜新生血管面积分别为35.4±3.5mm2,52.5±6.2mm2;雷公藤多甙组为30.0±2.7mm2,41.0±5.6mm2,实验组与对照组比较差异有显著性(P<0.05)。病理学检测结果显示,雷公藤多甙滴眼液点眼治疗对角膜组织无明显毒性作用。结论:雷公藤多甙滴眼液点眼治疗能显著抑制角膜新生血管的形成。AIM： To study the inhibition of Tripterygium Polyglucoside on chemical burn induced model of corneal neovascularization （CNV）. METHODS： A model of CNV was created by 750mL/L silver nitrate solution burn in 20 healthy rats which were subsequently randomized into two groups, the control group underwent normal saline eye drops, and the experimental group underwent Tripterygium Polyglucoside eye drops. After the chemical burns, the area of CNV was recorded and photographed, and the histology of cornea was evaluated under light microscopy. RESULTS： Fourteen and 28 days after creation of the model,the area of CNV in control group were 35.4±3.5mm2 and 52. 5± 6. 2mm2, respectively; the area of CNV in experimental group was 30.0±2.7mm2 and 41.0±5.6mm2, respectively. There was significant difference between the two groups （P〈 0. 05）. No obvious toxic effects of Tripterygium Polyglucoside eye drops to the corneal tissue were observed under the microscopy analysis. CONCLUSION： CNV can be significantly suppressed by the topical use of Tripterygium Polyglucoside eye drops.

关 键 词：雷公藤多甙 角膜新生血管化 大鼠 

分 类 号：R772.2[医药卫生—眼科]