Survivin蛋白和Fas蛋白在原发性翼状胬肉中的表达及其相关性研究  

Research of expression and correlation of Survivin and Fas in primary pterygium

作　　者：金玲[1,2] 许向前[3,4] 杨清秀[1,2] 张宏[1,2] 曹端荣[1,2] 李柏军[1,2] 

机构地区：[1]中国广东省深圳市宝安区人民医院眼科 [2]深圳市第八人民医院,518101 [3]中国广东省深圳市龙岗中心医院皮肤科 [4]深圳市第九人民医院,518101

出　　处：《国际眼科杂志》2012年第8期1543-1545,共3页International Eye Science

摘　　要：目的:探讨凋亡相关因子Survivin蛋白和Fas蛋白在原发性翼状胬肉组织的表达情况及其相互关系。方法:应用SP免疫组化法检测40例原发性翼状胬肉组织及20例正常结膜组织中Survivin,Fas蛋白的表达情况。所有数据应用SPSS11.5统计软件进行分析。结果:Survivin在原发性翼状胬肉组织中的表达阳性率(37.5%)高于正常结膜组织表达阳性率(10.0%),两者之间有显著差异性(P<0.05)。Fas在原发性翼状胬肉组织中的表达阳性率(75.0%)高于正常结膜组织表达阳性率(15.0%),两者之间有显著差异性(P<0.05);且Survivin和Fas两者的阳性表达率呈明显的正相关(P<0.01),表达强度具有一致性(P>0.05)。结论:Survivin可能与原发性翼状胬肉的发生密切相关;Survivin与Fas在原发性翼状胬肉组织中的表达关系密切,提示两者可能共同参与翼状胬肉的发生和发展。AIM ：To investigate the expression and relationship of Survivin and Fas in primary pterygium. METHODS： SP immunohistochemistry was used to detect the expression of Survivin protein and Fas protein in primary pterygium of 40 cases and nomal conjunctiva of 20 cases. All data were analyzed by SPSS 11.5. RESULTS： The positive expression of Survivin in pterygium （37. 5%） was higher than that in normal conjunctiva tissues （10. 0%, P〈 0. 05）. The positive expression of Fas in primary pterygium was significantly higher （75.0%）than that in normal conjunctiva tissues （15. 0%, P〈 0. 05）. There was a positive correlation between the expression rate of Survivin and Fas in primary pterygium （ P〈 0.01 ） and there was consistency between the expression strength of Survivin and Fas in primary pterygium（P〉0.05）. CONCLUSION： It indicated that Survivin may play an important role in the pathway of development of primary pterygium. There was a close correlation between the expression of Survivin and Fas in primary pterygium. It also indicated that Survivin and Fas may commonly participate in the occurrence and development of primary pterygium.

关 键 词：FAS蛋白 SURVIVIN蛋白 翼状胬肉 免疫组织化学 

分 类 号：R777.33[医药卫生—眼科]