EGCG对阿尔采末病的保护作用研究进展  

Research progress on the protective effect of EGCG on Alzheimer’s disease

作　　者：刘志男[1] 林原[1] 唐泽耀[1] 

机构地区：[1]大连医科大学药理学教研室,辽宁大连116044

出　　处：《中国药理学通报》2012年第8期1049-1053,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(30772601)

摘　　要：表没食子儿茶素没食子酸酯(epigaloctechin-3-gallit,EGCG)是一种高效的抗氧化剂。其通过恢复大脑内烟碱型胆碱能受体缺损及数量;降低C-Abl蛋白水平,一种非受体型酪氨酸激酶的核转移蛋白,阻碍β-亚型糖原合成激酶3(β-isoforms of glycogen synthase kinase 3,GSK-3β)活化,减轻阿尔茨海默氏病(Alzheimer's disease,AD)进程;抗氧化作用;改善线粒体功能失常;雌激素样等作用途径。起到下调淀淀粉样前体蛋白(amyloid precusor protein,APP)表达,加强清除Aβ作用,减轻对神经细胞的毒性,保护AD神经元功能。Epigaloctechin-3-gallit （ EGCG ） is a highly effective antioxidant. It improves Alzheimer＇ s disease （AD） by the way of restoring the defect and quantity of brain nicotinic cholinergic receptors, reducing the level of C-Abl protein, a nuclear transfer of nonreceptor tyrosine kinase, impeding the activation of β-isoforms of glycogen synthesis kinase 3 （ GSK-3β ）, opposing oxida- tion, improving mitochondrial dysfunction and acting on it like estrogen. As a result, it strengthens the clearance to Aβ by re- ducing the cytotoxicity of neuron and by down-regulating the ex- pression of Amyloid precusor protein （APP） so as to protect the function of Alzheimer＇ s neuron.

关 键 词：EGCG 阿尔采末病 清除Aβ作用 烟碱型胆碱能受体 CAbl蛋白 β亚型糖原合成激酶3 

分 类 号：R05[医药卫生] R282.71