黄酮类化合物的金属配合物及其药理作用  

Pharmacological activities and metal complexes for the flavonoids

作　　者：钱俊臻[1] 王伯初[1] 谭君[1] 刘玮琦[1] 

机构地区：[1]重庆大学生物工程学院,重庆400044

出　　处：《中国药理学通报》2012年第8期1058-1062,共5页Chinese Pharmacological Bulletin

基　　金：重庆大学研究生科技创新基金(No CDJXS11232241)

摘　　要：黄酮类化合物具有较高的超离域度,完整的大π键共轭体系,强配体氧原子与合适的空间构型,可作为金属离子的良好配体。该文综述了黄酮类化合物与金属配位的结构特点,分析和评价其抗肿瘤、抗氧化活性,并提出引入量子化学方法是金属配位化合物研究的一个重要的研究发展方向。Flavonoids exist in many kinds of plants and have many pharmacological activities. It can act as metallic chelator due to its peculiar structure. The chelate rule and pharmacological activities of anticancer and antioxidant of flavonoids-metal complexes are reviewed. Meanwhile, quantum chemistrion calculation for flavonoids-metal complexes is introduced to forecast the possible experimental results and the future tendency of these complexes is predicted.

关 键 词：黄酮类化合物 金属配位 药理作用 抗肿瘤 抗氧化 量子化学 

分 类 号：R05[医药卫生] R730.53