肠易煎联合化疗治疗大肠癌术后患者209例临床观察  

A Clinical Observation on Changyi Decoction Combined with Chemotherapy in 209 Cases of Postoperative Colorectal Cancer

作　　者：韩刚[1] 王以东[1] 曹羽[1] 龚航军[1] 窦丽萍[1] 钟薏[1] 

机构地区：[1]上海中医药大学附属曙光医院

出　　处：《中医杂志》2012年第14期1207-1209,共3页Journal of Traditional Chinese Medicine

基　　金：上海市教育委员会科研项目(07CZ022);上海市教育委员会科研创新项目(12ZZ123)

摘　　要：目的观察肠易煎对脾虚湿热型大肠癌术后患者血清血管内皮生长因子(VEGF)及肿瘤标志物的影响,探讨肠易煎的临床疗效。方法将符合纳入标准的402例结直肠癌术后患者随机分为治疗组209例和对照组193例,对照组给予单纯化疗,化疗方案为:奥沙利铂150mg/m2静脉滴注第1天+5-氟尿嘧啶(5-Fu)400mg/m2×5天静脉滴注+亚叶酸钙200mg/m2×5天为1个疗程,间隔21天进行下一个疗程,共治疗2个疗程。治疗组给予肠易煎联合化疗,肠易煎每日1剂,早晚分服。连续用药21天为1个疗程,共治疗2个疗程。观察两组患者治疗前后血清VEGF及肿瘤标志物[癌胚抗原(CEA),肿瘤标志物CA199、CA50、CA72]的变化。结果治疗组治疗后VEGF水平与治疗前比较差异有统计学意义(P<0.01);对照组治疗后VEGF水平与治疗前比较差异无统计学意义(P>0.05);两组治疗后VEGF水平比较差异有统计学意义(P<0.05)。治疗组治疗后CEA、CA50较治疗前差异有统计学意义(P<0.05),CA199和CA72无明显变化(P>0.05);对照组各指标治疗后与治疗前比较差异无统计学意义(P>0.05)。两组治疗后CEA、CA50比较差异有统计学意义(P<0.05)。结论肠易煎能够降低大肠癌术后患者VEGF表达水平,同时能降低CEA、CA50表达水平,表明抑制肿瘤血管新生可能是肠易煎抗肿瘤的有效途径之一。Objective To observe the therapeutic effect of Changyi Decoction （decoction for colorectal cancer） for postopera- tive coloreetal cancer patients with spleen deficiency and damp heat syndrome and its influence on serum vascular endothelial growth factor （VEGF） and tumor marks such as CEA, CA199, CA50 and CA724. Methods Totally 402 postoperative color- eetal cancer patients were randomized into the treatment group and control group, with 209 and 193 in each. The control group was given chemotherapy. The treatment group was given Changyi Decoction combined with chemotherapy. The serum VEGF and tumor marks such as CEA, CA199, CA50 and CA724 were observed before and after the treatment. Results After treat- ment, the serum VEGF changed significantly in the treatment group （P〈0.01）. There was significant difference in VEGF be- tween groups after treatment （P〈0. 05）. Comparing with the control group or before the treatment in group, the serum CEA and CA50 changed significantly in the treatment group （P〈0.05）. There was no significant difference in CA199 and CA72 be- tween groups or in group （P〉0.05）. There was no significant difference in the serum tumor marks before and after treatment in the control group （P〉0.05）. Conclusion Changyi Decoction is effective for coloreetal cancer and could decrease the ex- pression of VEGF, CEA and CA50, which maybe relevant to inhibiting tumor angiogenesis.

关 键 词：肠易煎 大肠癌 血管内皮生长因子 肿瘤标志物 

分 类 号：R735.34[医药卫生—肿瘤]