核/双壳医用磁性微球的研制  

The Preparation of Medical Nucleonic/bivalve Magnetic Microsphere

作　　者：苑星海[1] 林穗云[1] 

机构地区：[1]嘉应学院化学与环境学院,广东梅州514015

出　　处：《嘉应学院学报》2012年第5期53-56,共4页Journal of Jiaying University

基　　金：广东省科技计划项目(2005B16001065)

摘　　要：用共沉淀法制备Fe3O4磁性粒子,选用聚乙二醇和琼脂制备核/双壳医用磁性微球.最佳工艺条件为:Fe3+/Fe2+之比在1.70～1.75;沉淀剂25%NH3.H2O过量20～30%,在温度35℃,pH值11,反应时间为1h;琼脂的包覆最佳温度为50℃,pH值为9,时间1h;聚乙二醇包裹最佳温度为55℃,pH值为4,时间1h,可以通过调节搅拌速度和超声波分散时间控制Fe3O4粒子的尺度,实验确定包覆剂用量.并用透射电镜、分光光度计、古埃磁天平等进行了初步表征.Fe3O4 magnetic microsphere was prepared by coprecipitation method and medical nucleonic/bivalve mag- netic microsphere was prepared by polyethylene glycol or agar. The optimal condition of prepared Fe3O4 magnetic microsphere was that the ratio of Fe3＋/Fe2＋ was between 1.70 20 -30%, and the reaction time was lh at 35℃, and pH ic/bivalve magnetic microsphere was that the coating time time with polyethylene glycol was lh at 55℃, pH with 4. and 1.75; 25% NH3 H2O precipitant was above value was 11. The optimal condition of medical nucleon- with agar was lh at 50℃, pH with 9, and the coating The size of Fe3O4 was controlled by stirring speed and ul- trasonic. The characterizations of materials were investigated by projection electron microscopy, spectrophotometer and magnetic balance.

关 键 词：Fe3O4磁性微球 琼脂 聚乙二醇 

分 类 号：O611.4[理学—无机化学]