内镜微波联合抗HP治疗胃黏膜白斑的临床观察  

Clinical observation on endoscopic radiofrequency and anti-HP treatment for gastric mucosal leukoplakia

作　　者：冷明芳[1] 邱亚娟[1] 刘树旗[1] 王丽娇[1] 周红宇[1] 

机构地区：[1]解放军第169医院消化内科,湖南衡阳421002

出　　处：《临床军医杂志》2012年第3期576-577,共2页Clinical Journal of Medical Officers

摘　　要：目的研究内镜微波技术联合抗幽门螺杆菌(HP)治疗对胃黏膜白斑的治疗价值及远期疗效。方法将65例胃黏膜白斑且HP阳性患者,随机分为两组,即治疗组33例和对照组32例。在内镜直视下用微波电极侧面对胃黏膜白斑病灶进行滚压、烫熨式多点位治疗。治疗组微波治疗后常规抗HP治疗,对照组不服用抗HP药物。4周后及1年后内镜下复查。结果 (1)两组患者均未发生出血、穿孔等严重并发症。(2)治疗组失访3例,4周复查近期治愈率97%(29/30),对照组失访4例,近期治愈率为92.85%(26/28),两组比较,差异无统计学意义(P>0.05)。(3)治疗组1年后治愈率为93.1%(27/29),对照组为73.1%(19/26),两组比较,差异有统计学意义(P<0.05)。结论内镜下微波治疗胃黏膜白斑是一种安全有效的方法,联合抗HP治疗能有效减少复发,对胃癌早期预防有一定意义。Objective To study the therapeutic value and long-term effect of endoscopic radiofrequency and anti-HP for mueosal leukoplakia. Methods Sixty five cases of mucosal leukoplakia accompanied with HP-positive were divided into two groups （32 cases in control group and 33 cases in treatment group）, gastric mucosal lesions were watched directly and multi-point treated by rolling and ironing with the RF electrode side. The treatment group was treated by RF then conventional anti-HP, the control group was treated by RF then without anti-HP drugs. Patients were rechecked by endoscopy after 4 weeks and 1 year. Results （ 1 ） No complications such as bleeding, perforation occurred in two groups; （2） three eases in treatment group lost to follow up, the cure rate is 97% （29/30） ,4 cases in the control group were lost, the cure rate is 92.85% （26/28）. There was no significant difference between the two groups ; （ 3 ） after 1 year the cure rate was 93.1% （27/29） in treatment group, in the control group was 73.1% （ 19/ 26）, there were significant difference between two groups （P 〈 0.05 ）. Conclusion Endoscopic radiofrequency is a safe and effective method for gastric mucosal, with anti-HP therapy can effectively reduce the recurrence of gastric cancer, which is important in prevenuoa gastric cancer.

关 键 词：内镜 微波 胃黏膜白斑 幽门螺杆菌感染 

分 类 号：R573[医药卫生—消化系统]