Chemical Progress in Cyclopeptide-containing Traditional Medicines Cited in Chinese Pharmacopoeia  

作　　者：赵思蒙 邝彬 彭文文 贺文军 徐会敏 嵇长久 韩婧 郑玉清 宋卫武 谭宁华 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming,Yunnan 650201,China [2]Graduate University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Chinese Journal of Chemistry》2012年第6期1213-1225,共13页中国化学（英文版）

摘　　要：Plant cyclopeptides, cyclic compounds formed mainly by the peptidic bonds of 2--37 protein and non-protein amino acids （mainly L-amino acids） and found in higher plants, have been attractive for their extensive bioactivities and distinctive molecular architectures. During the last half century＇s study, about 500 cyclopeptides divided into eight types have been isolated from over 120 species, which belong to over 20 families and 60 genera. Some cyclopeptides showed potential anti-tumor, sedative, immunosuppressive, and uterotonic activities. In the Chinese Pharmacopoeia （CP, 2010 Version）, 23 species （14 families, 18 genera） containing cyclopeptides have been re- corded in the origins of 24 traditional Chinese medicines （TCMs）. Heterophyllin B （64）, first reported by us from Pseudostellaria heterophylla in 1993 was cited for the first time in CP as the standard substance of cyclopeptides for quality control. In this review, we highlight the progress in the chemical studies of these cyclopeptide-containing TCMs, in particular recent results in our group＇s publications.Plant cyclopeptides, cyclic compounds formed mainly by the peptidic bonds of 2--37 protein and non-protein amino acids （mainly L-amino acids） and found in higher plants, have been attractive for their extensive bioactivities and distinctive molecular architectures. During the last half century＇s study, about 500 cyclopeptides divided into eight types have been isolated from over 120 species, which belong to over 20 families and 60 genera. Some cyclopeptides showed potential anti-tumor, sedative, immunosuppressive, and uterotonic activities. In the Chinese Pharmacopoeia （CP, 2010 Version）, 23 species （14 families, 18 genera） containing cyclopeptides have been re- corded in the origins of 24 traditional Chinese medicines （TCMs）. Heterophyllin B （64）, first reported by us from Pseudostellaria heterophylla in 1993 was cited for the first time in CP as the standard substance of cyclopeptides for quality control. In this review, we highlight the progress in the chemical studies of these cyclopeptide-containing TCMs, in particular recent results in our group＇s publications.

关 键 词：CYCLOPEPTIDE traditional Chinese medicine chemical constituent 

分 类 号：S567.091[农业科学—中草药栽培] Q516[农业科学—作物学]