This work was supported by the National Key Research and Development Program of China(Grant No.2022YFE0104800 to Feng Han);the National Natural Science Foundation of China(Grant No.82003764 to Lili Feng);the Project supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.19KJB350001 to Lili Feng).
Glioblastoma(GBM)is a highly vascularized malignant brain tumor with poor clinical outcomes.Vasculogenic mimicry(VM)formed by aggressive GBM cells is an alternative approach for tumor blood supply and contributes to t...
financially supported by the National Natural Science Foundation of China(No.U1906213);the National Key Research and Development Program of China(No.2022YFC2804100)。
Four new cyclohexapeptides,pyridapeptides F–I(1–4),were isolated from the fermentation broth of marine sponge-derived Streptomyces sp.OUCMDZ-4539.The pyridapeptides F–H(1–3)are composed ofβ-hydroxyleucine,alanine...
financially supported by the National Natural Science Foundation of China(Nos.81322051 and 31400300);the Natural Science Foundation of Jiangsu Province(No.BK20151442);the Project Funded by the Priority Academic Program Development(PAPD) of Jiangsu Higher Education Institutions
Two cyclopeptides, celogentin L(1) and its epimer lyciumin A(2) were firstly isolated from Celosia argentea L.. The planar structures of the two compounds were fully determined by spectroscopic data, including 1 D-, 2...
funded by grants from the National Natural Science Foundation of China (Nos. 81360480, 81460536 and 81560571)
Neopeapyran(1),an unusual furo[2,3b]pyran analogue,together with a new cyclopeptide,turnagainolide C(2),were isolated from Streptomyces sp.S2236 associated with the rhizosphere soil of Panax notoginseng.The planar...
A novel dicyclopeptide-based bolaamphiphile was synthesized.The hydrophilic cyclopeptide fragments were linked to an alkyl chain 1,6-bis(maleimido)hexane,which acted as a hydrophobic spacer.The transmission electron m...
Plant cyclopeptides, cyclic compounds formed mainly by the peptidic bonds of 2--37 protein and non-protein amino acids (mainly L-amino acids) and found in higher plants, have been attractive for their extensive bioa...
An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review...
This project was supported by the National Basic Research Program of China(973 Program,2009CB522300);the National Natural Sciences Foundation of China(30830113);MOST(2009ZX09501-029).
A chemical investigation on the cultures of Xylaria carpophila led to the isolation of one known cyclopeptide cyclo(N-methyl-L-Phe-L-Pro-L-Leu-D-Ile-L-Val)(1),five new sesquiterpenes,named as xylcarpins A-E(2-6),and a...
supported by the Natural Science Foundation of Ynunan Province(No.2007B021M);Yurman University(No.2003Q008A).
A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo (-Thr-Gly-Pro-Tyr-Phe-) (1) and cyclo (-Ala-Gly-Ser-IIe-P...
Phakellistatin 13 is a good antitumor lead compound isolated from halobios. It was synthesized first time by solution method in combination of stepwise coupling and segment condensation. Final deprotection and cycliza...