CYCLOPEPTIDE

作品数:28被引量:42H指数:4
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相关领域:理学医药卫生更多>>
相关作者:刘明生陈英杰程永现邓世明谭宁华更多>>
相关机构:日本大学沈阳药科大学中国科学院更多>>
相关期刊:《Chinese Journal of Natural Medicines》《Science China Chemistry》《Journal of Biomedical Research》《中国药物化学杂志》更多>>
相关基金:国家自然科学基金中国科学院科研项目国家重点基础研究发展计划更多>>
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Cyclopeptide moroidin inhibits vasculogenic mimicry formed by glioblastoma cells via regulating β-catenin activation and EMT pathways被引量:1
《Journal of Biomedical Research》2024年第4期322-333,共12页Pengxiang Min Yingying Li Cuirong Wang Junting Fan Shangming Liu Xiang Chen Yamin Tang Feng Han Aixia Zhang Lili Feng 
This work was supported by the National Key Research and Development Program of China(Grant No.2022YFE0104800 to Feng Han);the National Natural Science Foundation of China(Grant No.82003764 to Lili Feng);the Project supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.19KJB350001 to Lili Feng).
Glioblastoma(GBM)is a highly vascularized malignant brain tumor with poor clinical outcomes.Vasculogenic mimicry(VM)formed by aggressive GBM cells is an alternative approach for tumor blood supply and contributes to t...
关键词:moroidin vasculogenic mimicry GLIOBLASTOMA EMT Β-CATENIN 
Pyridapeptides F–I,cyclohexapeptides from marine sponge-derived Streptomyces sp.OUCMDZ-4539
《Chinese Chemical Letters》2024年第7期341-344,共4页Shuige Zhao Pengcheng Yan Peipei Liu Haishan Liu Ning Li Peng Fu Weiming Zhu 
financially supported by the National Natural Science Foundation of China(No.U1906213);the National Key Research and Development Program of China(No.2022YFC2804100)。
Four new cyclohexapeptides,pyridapeptides F–I(1–4),were isolated from the fermentation broth of marine sponge-derived Streptomyces sp.OUCMDZ-4539.The pyridapeptides F–H(1–3)are composed ofβ-hydroxyleucine,alanine...
关键词:Marine microorganism STREPTOMYCES Cyclopeptide glycosides Pyridapeptides Antiproliferative activity 
A pair of cyclopeptide epimers from the seeds of Celosia argentea被引量:2
《Chinese Journal of Natural Medicines》2018年第1期63-69,共7页LIU Feng-Jie ZHU Zhi-Hua JIANG Yan LI Hui-Jun 
financially supported by the National Natural Science Foundation of China(Nos.81322051 and 31400300);the Natural Science Foundation of Jiangsu Province(No.BK20151442);the Project Funded by the Priority Academic Program Development(PAPD) of Jiangsu Higher Education Institutions
Two cyclopeptides, celogentin L(1) and its epimer lyciumin A(2) were firstly isolated from Celosia argentea L.. The planar structures of the two compounds were fully determined by spectroscopic data, including 1 D-, 2...
关键词:Celosia argentea CYCLOPEPTIDES Lyciumin A Celogentin L Absolute configuration 
Neopeapyran, an unusual furo[2,3b]pyran analogue and turnagainolide C from a soil Streptomyces sp. S2236
《Chinese Chemical Letters》2016年第7期1044-1047,共4页Hao Zhou Ya-Bin Yang Rong-Ting Duan Xue-Qiong Yang Ju-Cheng Zhang Xiao-Guang Xie Li-Xing Zhao Zhong-Tao Ding 
funded by grants from the National Natural Science Foundation of China (Nos. 81360480, 81460536 and 81560571)
Neopeapyran(1),an unusual furo[2,3b]pyran analogue,together with a new cyclopeptide,turnagainolide C(2),were isolated from Streptomyces sp.S2236 associated with the rhizosphere soil of Panax notoginseng.The planar...
关键词:Streptomyces sp. Furo[2 3b]pyran analogue CYCLOPEPTIDE Structure elucidation Antimicrobial activity 
Novel Cyclopeptide Bolaamphiphile for Constructing Supramolecular Nanotubes
《Chinese Journal of Chemistry》2014年第1期22-26,共5页Siyong Qin Qingrong Wang Yi Pei Mengyun Peng Renxi Zhuo Xianzheng Zhang 
A novel dicyclopeptide-based bolaamphiphile was synthesized.The hydrophilic cyclopeptide fragments were linked to an alkyl chain 1,6-bis(maleimido)hexane,which acted as a hydrophobic spacer.The transmission electron m...
关键词:CYCLOPEPTIDE BOLAAMPHIPHILE self-assembly NANOTUBE 
Chemical Progress in Cyclopeptide-containing Traditional Medicines Cited in Chinese Pharmacopoeia被引量:7
《Chinese Journal of Chemistry》2012年第6期1213-1225,共13页赵思蒙 邝彬 彭文文 贺文军 徐会敏 嵇长久 韩婧 郑玉清 宋卫武 谭宁华 
Plant cyclopeptides, cyclic compounds formed mainly by the peptidic bonds of 2--37 protein and non-protein amino acids (mainly L-amino acids) and found in higher plants, have been attractive for their extensive bioa...
关键词:CYCLOPEPTIDE traditional Chinese medicine chemical constituent 
Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases
《Acta Biochimica et Biophysica Sinica》2011年第10期757-762,共6页Wenyan Xu Liling Li Liangcheng Du Ninghua Tan 
An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review...
关键词:ribosomal peptide CYCLOPEPTIDES nonribosomal peptide synthetase cyclization mechanism 
Chemical investigation on the cultures of the fungus Xylaria carpophila被引量:5
《Natural Products and Bioprospecting》2011年第2期75-80,共6页Xia YIN Tao FENG Zheng-Hui LI Jia SU Yan LI Ning-Hua TAN Ji-Kai LIU 
This project was supported by the National Basic Research Program of China(973 Program,2009CB522300);the National Natural Sciences Foundation of China(30830113);MOST(2009ZX09501-029).
A chemical investigation on the cultures of Xylaria carpophila led to the isolation of one known cyclopeptide cyclo(N-methyl-L-Phe-L-Pro-L-Leu-D-Ile-L-Val)(1),five new sesquiterpenes,named as xylcarpins A-E(2-6),and a...
关键词:Xylaria carpophila SESQUITERPENES CYCLOPEPTIDE CYTOTOXICITY 
A new cyclopeptide from Dianthus caryophyllus被引量:1
《Chinese Chemical Letters》2008年第2期193-195,共3页Fei Li Feng Mei Zhang Ya Bin Yang Xue Qiong Yang Qiu E. Cao Zhong Tao Ding 
supported by the Natural Science Foundation of Ynunan Province(No.2007B021M);Yurman University(No.2003Q008A).
A new cyclopeptide as well as a known cyclopeptide were isolated from the whole plants of Dianthus caryophyllus. Their structures were elucidated as cyclo (-Thr-Gly-Pro-Tyr-Phe-) (1) and cyclo (-Ala-Gly-Ser-IIe-P...
关键词:CARYOPHYLLACEAE Dianthus caryophyllus CYCLOPEPTIDE Caryophllusin A 
Total Synthesis of Phakellistatin 13 by Solution Method被引量:1
《Chinese Chemical Letters》2006年第8期995-998,共4页Qing Feng JIANG You Jun ZHOU Jian Zhong YAO Jia Guo LU Ju ZHU Chun Quan SHENG Can Hui ZHENG Bing YAO 
Phakellistatin 13 is a good antitumor lead compound isolated from halobios. It was synthesized first time by solution method in combination of stepwise coupling and segment condensation. Final deprotection and cycliza...
关键词:Phakellistatin 13 solution-phase synthesis cyclopeptide. 
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