Novel Cyclopeptide Bolaamphiphile for Constructing Supramolecular Nanotubes  

作　　者：Siyong Qin Qingrong Wang Yi Pei Mengyun Peng Renxi Zhuo Xianzheng Zhang 

机构地区：Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, China Email: Xianzheng Zhang ([e-mail])[*]Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, Hubei 430072, China

出　　处：《Chinese Journal of Chemistry》2014年第1期22-26,共5页中国化学（英文版）

摘　　要：A novel dicyclopeptide-based bolaamphiphile was synthesized.The hydrophilic cyclopeptide fragments were linked to an alkyl chain 1,6-bis(maleimido)hexane,which acted as a hydrophobic spacer.The transmission electron microscopy (TEM) observation indicated that the cyclopeptide bolaamphiphile (CPB) self-assembled into the nanotubes with a thickness of about 3 nm.Based on the optimized molecular conformation obtained via MM2 method,the length of CPB was demonstrated to be around 4 nm,implying that the nanotubes were single-walled.Fourier transform infrared spectroscopy (FT-IR) and circular dichroism (CD) analysis showed that the cyclopeptides in CPB mainly acted as the hydrophilic headgroups,rather than providing the well-ordered hydrogen bonding interaction responsible for β-sheet conformation.To investigate the special self-assembly behavior of CPB,the single cyclopeptide (CP) without the connection of the linker was synthesized.Further investigation indicated that the CP molecules can not form tubular structures but nanofibers.A novel dicyclopeptide-based bolaamphiphile was synthesized.The hydrophilic cyclopeptide fragments were linked to an alkyl chain 1,6-bis(maleimido)hexane,which acted as a hydrophobic spacer.The transmission electron microscopy (TEM) observation indicated that the cyclopeptide bolaamphiphile (CPB) self-assembled into the nanotubes with a thickness of about 3 nm.Based on the optimized molecular conformation obtained via MM2 method,the length of CPB was demonstrated to be around 4 nm,implying that the nanotubes were single-walled.Fourier transform infrared spectroscopy (FT-IR) and circular dichroism (CD) analysis showed that the cyclopeptides in CPB mainly acted as the hydrophilic headgroups,rather than providing the well-ordered hydrogen bonding interaction responsible for β-sheet conformation.To investigate the special self-assembly behavior of CPB,the single cyclopeptide (CP) without the connection of the linker was synthesized.Further investigation indicated that the CP molecules can not form tubular structures but nanofibers.

关 键 词：CYCLOPEPTIDE BOLAAMPHIPHILE self-assembly NANOTUBE 

分 类 号：O6[理学—化学]