Pyridapeptides F–I,cyclohexapeptides from marine sponge-derived Streptomyces sp.OUCMDZ-4539  

作　　者：Shuige Zhao Pengcheng Yan Peipei Liu Haishan Liu Ning Li Peng Fu Weiming Zhu 

机构地区：[1]Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China [2]Key Laboratory for Marine Drugs and Bioproducts,Laoshan Laboratory,Qingdao 266237,China [3]School of Biological Science and Technology,University of Jinan,Ji'nan 250022,China [4]Key Laboratory for Biosensors of Shandong Province,Biology Institute,Qilu University of Technology,Ji'nan 250103,China

出　　处：《Chinese Chemical Letters》2024年第7期341-344,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.U1906213);the National Key Research and Development Program of China(No.2022YFC2804100)。

摘　　要：Four new cyclohexapeptides,pyridapeptides F–I(1–4),were isolated from the fermentation broth of marine sponge-derived Streptomyces sp.OUCMDZ-4539.The pyridapeptides F–H(1–3)are composed ofβ-hydroxyleucine,alanine,O-methylthreonine,hexahydropyridazine-3-carboxylic acid,5-hydroxytetrahydropyridazine-3-carboxylic acid,and(2S,3R,4E,6E)-2-amino-3–hydroxy-4,6-dienoic acid residues.Pyridapeptide I(4)contains(2S,3R,4E,6E)-2-amino-3–hydroxy-8-methylnona-4,6-dienoic acid residue and a very rare glycose residue,aculose.Their structures were determined based on spectroscopic analysis and chemical methods.Pyridapeptides G–I(2–4)have the 2,3,6-trideoxyhexose units glycosylated at theγ-OH-TPDA residue,displayed significant antiproliferative activity against four(PC9,MKN45,Hep G2,K562)or two(PC9,MKN45)human cancer cell lines.

关 键 词：Marine microorganism STREPTOMYCES Cyclopeptide glycosides Pyridapeptides Antiproliferative activity 

分 类 号：O629.72[理学—有机化学]