Neopeapyran, an unusual furo[2,3b]pyran analogue and turnagainolide C from a soil Streptomyces sp. S2236  

作　　者：Hao Zhou Ya-Bin Yang Rong-Ting Duan Xue-Qiong Yang Ju-Cheng Zhang Xiao-Guang Xie Li-Xing Zhao Zhong-Tao Ding 

机构地区：[1]Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University [2]Yunnan Institute of Microbiology, Yunnan University

出　　处：《Chinese Chemical Letters》2016年第7期1044-1047,共4页中国化学快报（英文版）

基　　金：funded by grants from the National Natural Science Foundation of China (Nos. 81360480, 81460536 and 81560571)

摘　　要：Neopeapyran（1）,an unusual furo[2,3b]pyran analogue,together with a new cyclopeptide,turnagainolide C（2）,were isolated from Streptomyces sp.S2236 associated with the rhizosphere soil of Panax notoginseng.The planar structure and relative configuration of neopeapyran（1） were elucidated on the basis of spectroscopic techniques,while the absolute configuration was determined by TDDFT calculation.The absolute configuration of turnagainolide C（2） was determined by partial hydrolysis,together with the advanced Marfey’s method and spectroscopic analysis.The antimicrobial activities of these two compounds were also investigated.Neopeapyran（1）,an unusual furo[2,3b]pyran analogue,together with a new cyclopeptide,turnagainolide C（2）,were isolated from Streptomyces sp.S2236 associated with the rhizosphere soil of Panax notoginseng.The planar structure and relative configuration of neopeapyran（1） were elucidated on the basis of spectroscopic techniques,while the absolute configuration was determined by TDDFT calculation.The absolute configuration of turnagainolide C（2） was determined by partial hydrolysis,together with the advanced Marfey’s method and spectroscopic analysis.The antimicrobial activities of these two compounds were also investigated.

关 键 词：Streptomyces sp. Furo[2 3b]pyran analogue CYCLOPEPTIDE Structure elucidation Antimicrobial activity 

分 类 号：R915[医药卫生—微生物与生化药学] O626[医药卫生—药学]