ent-Kaurane Diterpenoids from Isodon eriocalyx var. laxiflorat  

作　　者：汪伟光 吴海燕 杜雪 普建新 孙汉董 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kuming,Yunan 650201,China [2]Graduate School of the Chinese Academy of Sciences,Kuming,Yunan 650201,China

出　　处：《Chinese Journal of Chemistry》2012年第6期1226-1230,共5页中国化学（英文版）

摘　　要：Four new ent-kaurane diterpenoids, 6fl,13ct,15fl-trihydroxy-16-ene-3a,20-epoxy-ent-kaur- 1,7-dione （1）, 6-hydroxy-3a,20-epoxy-5（6）-ene-ent-kaur-l,7,15-trione （2）, 6-hydroxy-15fl-acetoxy-3a,20-epoxy-16]3,17-epoxy- 5（6）-ene-ent-kaur-l,7-dione （3）, 3ct,17-dihydroxy-15（16）-ene-ent-kaur-7-one （4）, along with four known com- pounds 5--8 were isolated from the leaves oflsodon eriocalyx var. laxiflora. The structures were elucidated by ex- tensive spectroscopic methods （IR, UV, MS and NMR）. The cytotoxic activities of these compounds were evaluated by MTT assay. Compound 8 showed moderate inhibitory effects on HL-60, SMMC-7721, MCF-7 and SW-480 cell lines.Four new ent-kaurane diterpenoids, 6fl,13ct,15fl-trihydroxy-16-ene-3a,20-epoxy-ent-kaur- 1,7-dione （1）, 6-hydroxy-3a,20-epoxy-5（6）-ene-ent-kaur-l,7,15-trione （2）, 6-hydroxy-15fl-acetoxy-3a,20-epoxy-16]3,17-epoxy- 5（6）-ene-ent-kaur-l,7-dione （3）, 3ct,17-dihydroxy-15（16）-ene-ent-kaur-7-one （4）, along with four known com- pounds 5--8 were isolated from the leaves oflsodon eriocalyx var. laxiflora. The structures were elucidated by ex- tensive spectroscopic methods （IR, UV, MS and NMR）. The cytotoxic activities of these compounds were evaluated by MTT assay. Compound 8 showed moderate inhibitory effects on HL-60, SMMC-7721, MCF-7 and SW-480 cell lines.

关 键 词：ent-Kaurane diterpenoid ISODON structure elucidation cytotoxicity 

分 类 号：Q949.758.8[生物学—植物学] TQ463[化学工程—制药化工]