散发性阿尔茨海默病早期诊断标志物的研究进展  

Biomarkers of Early Diagnosis of Sporadic Alzheimer's Disease

作　　者：郜丽妍[1] 李晓红[2] 刘萍[2] 

机构地区：[1]大连医科大学,辽宁大连116044 [2]大连市友谊医院,辽宁大连116001

出　　处：《医学与哲学（B）》2012年第6期41-42,65,共3页Medicine & Philosophy(B)

摘　　要：散发性阿尔茨海默病早期诊断标志物的研究对延长患者生存时间,提高患者生活质量,减轻社会负担都具有重要意义。本文就目前各种可能的早期标志物进行综述,包括Aβ、tau蛋白、β内分泌酶、同型半胱氨酸、维生素B12、叶酸、胰岛素、人组织型激肽释放酶6等。鉴于其复杂性,仍有很多问题亟待我们去解决。Alzheimer＇s disease has always been diagnosed at its moderate and severe stage, and medicines are not so effective, as a result,early diagnosis of this disease has a vital significance. In this article, we reviewed several possible biomarkers, including Aβ, tau protein, β-site amyloid precursor protein cleavage enzyme 1, Hcy, Vitamin B12, foliate, insulin, HK6, etc. In view of its complexity,there are still a lot of problems that should be solved.

关 键 词：散发性阿尔茨海默病 生物学标志物 早期诊断 

分 类 号：R741.04[医药卫生—神经病学与精神病学]