HBHA在结核病研究中的应用  

Application of Mycobacterium Tuberculosis Adhesion HBHA in Tuberculosis Research

作　　者：江鹰[1] 赵善民[1] 师长宏[1] 

机构地区：[1]第四军医大学实验动物中心,陕西西安710032

出　　处：《现代生物医学进展》2012年第17期3347-3349,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30972767)

摘　　要：结核分枝杆菌hbhA编码基因是目前发现的与肺外结核转移相关的基因,其表达产物结核分枝杆菌肝素结合血凝黏附素(HBHA),是结核分枝杆菌表面表达和分泌的一种糖蛋白。HBHA具有介导肺结核和肺外结核的发生,参与实现MTB逃逸吞噬体进入细胞质中生存和繁殖,引起巨噬细胞凋亡等重要生物学功能,同时HBHA作为特异性抗原,用作免疫学检测具有较好的效果,并且动物实验证实HBHA具有明确的免疫治疗作用。因此,HBHA在结核病的免疫学诊断及免疫治疗方面,具有广阔的应用前景。The hbhA Gene of M.tuberculosis mediates extra-pulmonary dissemination and its expression product,the HeparinBinding Haemagglutinin（HBHA）,is a bacterial glycoprotein exposed on the surface of M.tuberculosis.HBHA can involve in the extrapulmonary dissemination,participate in the escape of mycobacteria from the phagosome,cause apoptosis of macrophages and other important biological functions.Meanwhile,HBHA as the specific antigen used for the detection of antibodies had good results and positive therapeutic effect in laboratory animals.Therefore,HBHA has a broad application prospect in tuberculosis research,especially in the immunological detection and immunotherapy.

关 键 词：结核分枝杆菌 HBHA 生物学功能 应用 

分 类 号：R378.911[医药卫生—病原生物学]