利用纳米SiO_2模板制备壳聚糖季铵盐/海藻酸钠自组装微胶囊的研究  

Preparation of Quaternary Chitosan/Sodium Alginate Self-assembled Microcapsules on the Template of Nano-SiO_2 Particles

作　　者：李栋[1] 王小慧[1] 孙润仓[1,2] 

机构地区：[1]华南理工大学制浆造纸工程国家重点实验室,广东广州510640 [2]北京林业大学生物质化学与技术研究所,北京100083

出　　处：《造纸科学与技术》2012年第3期32-36,共5页Paper Science & Technology

基　　金：国家自然科学基金(51103046)资助项目;国家973计划项目(2010CB732204;2010CB732201);广东省科技计划国际合作项目(2011B050400015)

摘　　要：分别以壳聚糖季铵盐和海藻酸钠为阳离子组分和阴离子组分,采用高分子聚电解质的层层自组装(LBL)技术在纳米二氧化硅微球(SiO2)模板上构建自组装多层膜,获得了核/壳结构微胶囊。结果显示这种微胶囊的平均粒径为396.4 nm,平均每个单分子沉积层的厚度约为2.5 nm。通过罗丹明B对自组装微胶囊的囊壁材料进行修饰,在荧光显微镜下观察到微胶囊分布均匀,且发出明亮的红色荧光。进而,通过稀氢氟酸溶液去除SiO2核模板,成功获得了壳聚糖季铵盐/海藻酸盐空心微胶囊。这种空心微胶囊作为一种新型的包载活性物质的载体将有望在功能纸、药物控制释放和酶的固定化等领域发挥重要的作用。Core-shell structured microcapsules were prepared through polyelectrolyte layer-by-layer （LBL） self-assembly by using quaternary chitosan as positive part, sodium alginate as negative part, and nanosized SiO2 particles age thickness of each mono - molecular deposition layer is 2.5 nm. The core-shell structured microcapsules were observed under fluorescence microscope after the shell materials of the microcapsules were labeled with Rodamine B. It can he observed that the microcapsules with bright red light emission are uniformly dispersed. Hollow micro- capsules were successfully obtained by dissolving SiO2 core material with dilute hydrofluoric acid solution. These natural polysaccharides based microcapsules are expected to be applied in wide fields including specific paper, drug delivery and enzyme immobilization, etc.

关 键 词：壳聚糖季铵盐 海藻酸钠 LBL自组装 微胶囊 

分 类 号：TQ321[化学工程—合成树脂塑料工业]