白细胞介素-1基因多态性与缺血性脑卒中相关性  

THE RELATIONSHIP BETWEEN INTERLEUKIN-1 GENE POLYMORPHISM AND ISCHEMIC STROKE

作　　者：宋博[1] 李聪[1] 孙蕾[1] 周畅[1] 王海萍[1] 张晨[1] 

机构地区：[1]青岛大学医学院附属医院神经内科,山东青岛266003

出　　处：《青岛大学医学院学报》2012年第4期313-316,320,共5页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省自然科学基金资助项目(ZR2010HM061)

摘　　要：目的探讨白细胞介素(IL)-1α-889C/T和IL-1β-511C/T基因多态性与缺血性脑卒中(IS)的相关性。方法采用病例对照研究,对440例IS病人和486例对照人群应用聚合酶链反应限制性片段长度多态性的方法检测IL-1α-889C/T和IL-1β-511C/T两个位点基因多态性。比较两组基因型及等位基因分布频率。用Logistic回归方法调整传统危险因素后分析基因多态性与IS发病的相关性。结果 IS组及大动脉粥样硬化型亚组IL-1α-889C/T基因型分布及等位基因频率与对照组比较差异具有显著性(χ2=7.623～14.152,P<0.05)。IS组及其亚组IL-1β-551C/T基因型及IL-1β-511T等位基因的分布频率与对照组比较差异无显著性。IL-1α-889TT基因型与IS的发病具有相关性,是IS的重要危险因素(OR=1.304,P<0.01)。结论 IL-1α-889C/T基因多态性可能增加IS的发病风险,IL-1β-511C/T基因多态性可能与IS的发病无关。Objective To investigate the relationship between interleukin （IL）-lα-889 C/T, IL 1β-511C/T gene poly- morphism and ischemic stroke （IS）. Methods A case-control study was conducted in 440 IS patients and 4,86 controls. The IL- 1α-889 C/T and IL-Iβ-511C/T gene polymorphism were detected by using polymerase chain reaction （PCR） and restrictive frag- ment length polymorphism （RFLP）. The genetype and allele distribution were compared between the two groups. The association of the gene polymorphism with the risk of ischemic stroke as analyzed by logistic regression after adjustion of confounding varia- bles. Results The differences of distribution of IL-lα-889 C/T genetype and allele frequency between IS and its subset and con- trols were significant （X^2 =. 623-14.152, P〈0.05）, and the differences between the two groups were not significant in terms of IL-113-511C/T genetype and allele frequency. IL-lα-889 TT allele was associated with the onset of IS, being a risk factor for the diasese （OR=I. 304,P〈0.01）. Conclusion ＇ IL-lα-889 C/T gene polymorphism may increase the risk of IS, and that of IL-113 -511C/T is no likelihood of the onset of this condition.

关 键 词：脑血管意外 白细胞介素1 多态性 单核苷酸 

分 类 号：R743.3[医药卫生—神经病学与精神病学]