甘氨双唑钠并同步放化疗对Ⅱ～Ⅲ期宫颈癌近期疗效  

SHORT-TERM EFFICACY OF CONCURRENT CHEMORADIOTHERAPY WITH SODIUM GLYEIDIDAZOLE FOR STAGE Ⅱ AND Ⅲ CERVIX CARCINOMA

作　　者：徐丽娟[1] 于壮[1] 史小利[1] 张永春[1] 

机构地区：[1]青岛大学医学院附属医院肿瘤科,山东青岛266003

出　　处：《齐鲁医学杂志》2012年第5期398-400,共3页Medical Journal of Qilu

摘　　要：目的观察注射用甘氨双唑钠在中晚期宫颈癌根治性放化疗中的增敏作用,评价其近期疗效及副作用。方法将230例Ⅱ、Ⅲ期宫颈癌病人随机分为2组。对照组108例病人行根治性放疗联合同期化疗2周期,放射治疗采用直线加速器6MV-X线盆腔对穿外照射同时结合腔内后装治疗,放疗开始第1天同期应用FLP方案化疗,第28天重复。治疗组122例病人放化疗方案同对照组,同时在每周一、三、五放疗前静脉滴注注射用甘氨双唑钠。结果治疗组半程放疗后肿瘤直径缩小较对照组明显(t=2.521,P<0.05)。全程放疗结束时治疗组肿瘤完全缓解率较对照组明显提高(χ2=4.59,P<0.05)。两组放射性直肠炎、放射性膀胱炎及中性粒细胞减少等3种急性放射性损伤比较无统计学差异(P>0.05)。结论注射用甘氨双唑钠可以使肿瘤消退加速,提高肿瘤完全缓解率,且不增加放化疗急性毒副作用。Objective To evaluate the sensitization of ehemoradiotherapy of Glycididazolum natrium （CMNa） and its short-term efficacy and side effects for intermediate and advanced-stage cervix carcinoma （CC）. Methods This sduty was con- sisted of 230 CC patients, who were classified as stage Ⅱ orⅢ and divided into treatment and control group in random. The pa- tients in the control group （108 cases） were treated with radical radiotherapy combined with chemotherapy for two cycles, 6-MV linear accelerator combined with brachytherapy were applied. On the first day of radiotherapy, PLF schedule started and repeated on day 28; for those in the treatment group, the schedule of radiochemotherapy was the same as done in the control group, and, at the same time, intravenous drip of CMNa was carried out on Monday, Wednesday and Friday prior to radiation. Results The diameter of tumors in the treatment group reduced more obviously than that in the control after a half-course of radiation （t= 2. 521 ,P〈O. 05）. Upon completion of the whole course of radiotherapy, the complete remission （CR） rate was significantly higher in the treatment group vs the control （x^2=4.59,P〈0.05）. The acute radiation damages, such as radiation proctitis, cystitis and neutropenia,were not statistically different between the two groups （P〉0.05）. Conclusion injection of CMNa can accelerate resolution of tumor, raise the rate of complete remission, and not increase the adverse reactions caused by radiochemotherapy.

关 键 词：宫颈肿瘤 甘氨双唑钠 放射疗法 药物疗法 辐射增敏药 

分 类 号：R737.33[医药卫生—肿瘤]