磷酸肌酸钠治疗急性轻中度脑梗死的临床疗效观察  

Clinical observation of the efficacy of treatment mild acute cerebral infarction with phosphocreatine sodium

作　　者：路屹[1] 马博[1] 张丽娜[1] 许力[1] 谢静[1] 屈洪党[1] 赵瑾[2] 

机构地区：[1]蚌埠医学院第一附属医院神经内科,蚌埠233004 [2]蚌埠医学院病理生理学教研室

出　　处：《南通大学学报（医学版）》2012年第4期283-285,共3页Journal of Nantong University(Medical sciences)

基　　金：安徽省卫生厅科研项目(2010B024);安徽省教育厅科研项目(KJ2010B122)

摘　　要：目的:观察磷酸肌酸钠治疗急性轻、中度脑梗死的疗效。方法:43例急性脑梗死患者,分为治疗组22例,给予磷酸肌酸钠治疗;对照组21例,给予常规治疗;并分别于治疗前、后14 d采用美国国立卫生院卒中量表(NationalInstitutes of Health Stroke Scale,NIHSS)及改良Rankin量表(modified Rankin Scale,mRS)评定患者的神经功能缺失程度以及日常生活活动的依赖和病残程度。结果:两组患者治疗前、后的NIHSS评分和mRS评分均降低,但治疗组治疗后的NIHSS评分和mRS评分降低较对照组明显,治疗组治疗后的NIHSS评分和mRS评分较治疗前明显降低(P<0.05)。结论:磷酸肌酸钠对提高急性轻中度脑梗死的疗效有助。Objective： To investigate the efficacy of treatment mild acute cerebral infaretion（ACI） with phosphocreatine sodium. Methods： 43 cases with ACI were divided into the treatment group （22 cases）, which were treated with phosphocreatine sodium and the control group （21 cases）, which were treated with conventional therapy. The National Institutes of Health Stroke Scale（NIHSS） and the modified Rankin Scale（mRS） of all cases were evaluated on the days 14 before and after treatment. Results： The scores of NIHSS and mRS of two groups decreased and the scores of treatment group were lower than that of the control group （P〈0.05） after therapy. The scores of NIHSS and mRS of treaty groups were improved obviously with before therapy. Conclusion： Treatment mild ACI with phosphocreatine sodium is safety and effective, which is worth popularizing in clinic.

关 键 词：急性轻中度脑梗死 磷酸肌酸钠 治疗效果 

分 类 号：R743.3[医药卫生—神经病学与精神病学]